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Your search keyword '"Gogate, Bageshri P"' showing total 4 results
Start Over Author "Gogate, Bageshri P" Publisher medknow
4 results on '"Gogate, Bageshri P"'

1. A rare case of Pleuropulmonary blastoma type III with Immunohistochemical Study.

Author

Sinai Khandeparkar SG, Kulkarni MM, Gogate BP, and Dhavan CS

Subjects
Humans, Male, Child, Lung Neoplasms diagnosis, Lung Neoplasms pathology, Pleural Neoplasms diagnosis, Pulmonary Blastoma diagnosis, Cysts pathology
Abstract

Here we intend to document a rare case of PPB type III in a 2-year male presenting with an extensive tumor occupying the right hemithorax with immunohistochemical (IHC) study. Pleuropulmonary blastoma (PPB) is a rare variably aggressive, dysodontogenetic, childhood primary intrathoracic malignancy which in up to 25% of cases can be extrapulmonary with attachment to the parietal pleura. It is found in pediatric population under 5 years of age. It was initially proposed as a distinct entity by Manivel et al. in 1988. PPB is a proliferation of primitive mesenchymal cells that initially form air-filled cysts lined by benign-appearing epithelium (type I, cystic). Later on, the mesenchymal cells outgrow the cysts with formation of focal solid areas (type II, solid and cystic) and finally, mainly solid mass (type III, solid PPB)., Competing Interests: None

Published
2023
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2. A rare case of Kimura's disease involving parotid gland, lymph nodes, skin, and subcutaneous tissue diagnosed on frozen section.

Author

Sinai Khandeparkar SG, Aphale V, Bharti N, Gogate BP, and Solanke S

Subjects
Adolescent, Humans, India, Lymph Nodes cytology, Magnetic Resonance Imaging, Male, Parotid Gland cytology, Skin cytology, Frozen Sections methods, Kimura Disease complications, Kimura Disease diagnostic imaging, Lymph Nodes pathology, Parotid Gland pathology, Skin pathology, Subcutaneous Tissue pathology
Abstract

Competing Interests: None

Published
2021
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3. A rare case of cerebellar pilomyxoid astrocytoma associated with neurofibromatosis-1 in a young female; case report highlighting immunohistochemical features.

Author

Sinai Khandeparkar SG, Gosavi SS, Gogate BP, and Talathi N

Subjects
Adult, Astrocytoma diagnosis, Brain Neoplasms diagnosis, Female, Humans, Immunohistochemistry, Magnetic Resonance Imaging, Astrocytoma pathology, Brain Neoplasms pathology, Neurofibromatosis 1 complications, Pilomatrixoma pathology
Abstract

Pilomyxoid astrocytoma (PMA), a distinct clinico-histopathological entity in the World Health Organization classification 2007, tends to be locally aggressive, with higher chance of leptomeningeal dissemination, recurrence, and poor prognosis. PMA is generally seen in young children and tend to occur in the hypothalamic-chiasmatic region. Their presence in other parts of the brain in the non pediatric age group is uncommon. To the best of our knowledge we are presenting first case of cerebellar PMA associated with neurofibromatosis 1 (NF1) in a 40-year- old female, with immunohistochemical study., Competing Interests: None

Published
2021
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4. Immunohistochemical expression of cyclin D1 in invasive breast carcinoma and its correlation with clinicopathological parameters.

Author

Lengare PV, Sinai Khandeparkar SG, Joshi AR, Gogate BP, Solanke SG, and Gore SH

Subjects
Adult, Aged, Biomarkers, Tumor, Breast Neoplasms diagnosis, Breast Neoplasms pathology, Cross-Sectional Studies, Female, Humans, Immunohistochemistry methods, Middle Aged, Tertiary Care Centers, Tissue Array Analysis, Breast Neoplasms genetics, Cyclin D1 genetics
Abstract

Introduction: Breast cancer (BC) is the most common cancer and leading cause of death in women., Aim: This study was conducted to study the cyclin D1 expression in BC and its correlation with other clinicopathological parameters such as tumor size, histological grade, lymph node status, estrogen receptor (ER), progesterone receptor (PR), HER2/neu, and Ki67 status., Materials and Methods: Fifty cases of BC diagnosed between 2015 and 2018 were included in the study. A technique of manual tissue microarray was employed for the analysis of expression of immunohistochemical (IHC) markers such as cyclin D1, ER, PR, HER2/neu, and Ki67 in all cases. Results were subjected to statistical analysis., Results: Cyclin D1 positivity was seen in 64% cases of BC cases of which 8% were triple negative BC (TNBC) molecular subtype. Cyclin D1 expression was statistically significantly associated with ER and PR positivity. Maximum cases showing cyclin D1 expression showed negative HER2/neu expression, Ki67 immunopositivity, absent lymphovascular invasion and were of lower grade and stage. 32% cases were TNBC. Cyclin D1 was found positive in 25% TNBC cases. Negative Cyclin D1 expression was seen in TNBC cases of higher grade and higher stage with positive lymph node status, presence of lymphovascular invasion and Ki67 positivity., Conclusion: Cyclin D1 can be potentially used as a prognostic marker and if included in routine IHC workup of BC cases can aid in appropriate patient management with the advent of new targeted therapy that blocks the cyclin D-CDK4/6 axis.

Published
2020
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