1. Typhoid fever & vaccine development: a partially answered question.
- Author
-
Marathe SA, Lahiri A, Negi VD, and Chakravortty D
- Subjects
- Clinical Trials as Topic, Drug Resistance, Multiple genetics, Humans, Polysaccharides, Bacterial therapeutic use, Salmonella Infections prevention & control, Salmonella typhi immunology, Typhoid Fever immunology, Typhoid Fever microbiology, Typhoid-Paratyphoid Vaccines classification, Vaccines, Attenuated therapeutic use, Vaccines, DNA immunology, Vaccines, DNA therapeutic use, Salmonella typhi pathogenicity, Typhoid Fever prevention & control, Typhoid-Paratyphoid Vaccines therapeutic use
- Abstract
Typhoid fever is a systemic disease caused by the human specific Gram-negative pathogen Salmonella enterica serovar Typhi (S. Typhi). The extra-intestinal infections caused by Salmonella are very fatal. The incidence of typhoid fever remains very high in impoverished areas and the emergence of multidrug resistance has made the situation worse. To combat and to reduce the morbidity and mortality caused by typhoid fever, many preventive measures and strategies have been employed, the most important being vaccination. In recent years, many Salmonella vaccines have been developed including live attenuated as well as DNA vaccines and their clinical trials have shown encouraging results. But with the increasing antibiotic resistance, the development of potent vaccine candidate for typhoid fever is a need of the hour. This review discusses the latest trends in the typhoid vaccine development and the clinical trials which are underway.
- Published
- 2012