1. CCND1 rs9344 polymorphism is associated with the risk of hepatocellular carcinoma in Caucasian population.
- Author
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Wang DD, Duan WD, Zhu ZM, Tu YL, Dou CQ, Han MM, Zhang B, Zhao W, and Jiang K
- Subjects
- Asian People genetics, Case-Control Studies, Genetic Association Studies, Humans, Odds Ratio, Publication Bias, Risk Assessment, Risk Factors, Alleles, Carcinoma, Hepatocellular genetics, Cyclin D1 genetics, Genetic Predisposition to Disease, Liver Neoplasms genetics, Polymorphism, Single Nucleotide, White People genetics
- Abstract
Aims: Some studies investigated the association between CCND1 rs9344 polymorphism and hepatocellular carcinoma (HCC) risk. However, the results were inconclusive. Thus, we did a meta-analysis to determine this relationship., Materials and Methods: Relevant studies were systematically searched using the PubMed, CNKI, and EMBASE databases. The strength of the association was calculated with the odds ratio (OR) and respective 95% confidence intervals (Cis)., Results: We investigated the association between CCND1 rs9344 polymorphism and HCC risk in the dominant models. The result of this meta-analysis showed that CCND1 rs9344 polymorphism did not significantly associated with HCC risk (OR = 1.09; 95% CI 0.88-1.34). In the stratified analysis by ethnicity, we found that this polymorphism was significantly associated with HCC risk in Caucasians (OR = 1.55; 95% CI, 1.05-2.29). However, we did not find any significant association between this polymorphism and HCC risk in Asians (OR = 0.91; 95% CI, 0.71-1.18)., Conclusions: This meta-analysis suggested that CCND1 rs9344 polymorphism might be associated with the risk of HCC among Caucasians., Competing Interests: There are no conflicts of interest
- Published
- 2018
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