1. A novel CCK2/gastrin receptor-localizing radiolabeled peptide probe for personalized diagnosis and therapy of patients with progressive or metastatic medullary thyroid carcinoma: A multicenter phase I GRAN-T-MTC study
- Author
-
Georg Goebel, Mark Konijnenberg, Helmut R. Maecke, Petra Kolenc Peitl, Paola Anna Erba, Piotr Garnuszek, Elisabeth von Guggenberg, Christine Rangger, Marion de Jong, Alicja Hubalewska-Dydejczyk, Irena Virgolini, Renata Mikolajczak, Clemens Decristoforo, Lorenza Scarpa, Berthold A. Nock, Alida Froberg, Anna Sowa-Staszczak, Katja Zaletel, Dariusz Pawlak, Monika Tomaszuk, Wioletta Lenda-Tracz, Malgorzata Trofimiuk-Muldner, Theodosia Maina-Nock, Agata Jabrocka-Hybel, Erba, P, Maecke, H, Mikolajczak, R, Decristoforo, C, Zaletel, K, Maina-Nock, T, Peitl, P, Garnuszek, P, Froberg, A, Goebel, G, De Jong, M, Jabrocka-Hybel, A, Konijnenberg, M, Virgolini, I, Nock, B, Lenda-Tracz, W, Pawlak, D, Rangger, C, Trofmiuk-Muldner, M, Sowa-Staszczak, A, Tomaszuk, M, Von Guggenberg, E, Scarpa, L, Hubalewska-Dydejczyk, A, and Radiology & Nuclear Medicine
- Subjects
0301 basic medicine ,Oncology ,Adult ,Male ,PHARMACOKINETICS ,medicine.medical_specialty ,Medullary cavity ,Early detection ,Disease ,Article ,Thyroid carcinoma ,03 medical and health sciences ,0302 clinical medicine ,Clinical Protocols ,Internal medicine ,Internal Medicine ,medicine ,Carcinoma ,Humans ,Multicenter Studies as Topic ,Thyroid Neoplasms ,Neoplasm Metastasis ,Receptor ,Clinical Protocol ,Gastrin ,Randomized Controlled Trials as Topic ,business.industry ,medicine.disease ,Receptor, Cholecystokinin B ,Carcinoma, Neuroendocrine ,Neoplasm Metastasi ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cholecystokinin B receptor ,Female ,business ,Human - Abstract
Medullary thyroid carcinoma (MTC) is one of the most challenging cancers. Epidemiological studies have shown that during the past 30 years neither a change in stage at diagnosis nor a significant improvement in survival has been achieved. Therefore, new diagnostic and therapeutic strategies are needed for early detection of metastases or disease recurrence and tumor growth control.
- Published
- 2018