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Introduction: Surgery is recommended following endoscopic polypectomy for malignant adenoma (MA) in the large bowel in patients with risk factors for tumor recurrence or distant metastasis are present., Objectives: We present long‑term outcomes of a prospective study in patients with endoscopically removed MAs., Patients and Methods: A total of 128 patients who underwent endoscopic polypectomy were followed up for a median of 70.4 months. The criteria for adequate polypectomy included endoscopically and histologically (margin ≥2 mm) complete excision, lack of angioinvasion, and good tumor differentiation (G1 or G2). Sixty‑seven patients did not meet 1 or more of the criteria (high‑risk group) and 61 met all of the criteria (low‑risk group). Unfavorable outcomes were residual disease, lymph node metastasis, recurrent disease, distant metastasis, or death due to colorectal cancer. Histological samples from 85 patients were reassessed to determine the effect of a margin width of 1 mm or more and tumor budding on the outcomes., Results: Surgery was performed in 36 patients (28.1%), of whom 32 (47.7%) were high‑risk and 4 (6.5%) were low‑risk. Unfavorable outcome was observed in 10 patients (7.8%; all high‑risk; 10 of 67 patients, 14.9%). Favorable outcome was observed in 61 of 128 patients who had a 2‑mm free margin, and in 44 of 85 patients who fulfilled the modified criterion of 1‑mm free margin. Tumor budding was detected in 17 of 85 patients (20.9%). Unfavorable outcome was observed in 2 of these patients (11.7%) and in 5 patients (7.3%) without tumor budding (P >0.05)., Discussion: Long‑term outcomes of an endoscopic resection of MAs are good. Bowel resection does not prevent unfavorable outcomes, while a reduction of the tumor‑free margin would not deteriorate the results (STROBE 1B).

Introduction: The incidence and prevalence of inflammatory bowel disease (IBD) in Poland is unknown., Objectives: We aimed to define the rates of hospitalization for IBD and time trends in the past 2 decades., Patients and Methods: Data were obtained from the database of the National Institute of Public Health (1991-1996 and 2003-2007). Data on hospitalizations for Crohn's disease (CD) and ulcerative colitis (UC) were extracted. Age-, sex-, and disease‑specific rates of hospitalization per 100,000 population were calculated., Results: During the years 1991-1996 and 2003-2007, the rate of hospitalization for IBD increased each year, rising from 12.50 to 30.61 per 100,000 population. Rising time trends were observed in both sexes. The hospitalization rate increased from 3.53 to 9.35 per 100,000 population for CD and from 8.97 to 21.26 per 100,000 population for UC. A rising time trend was observed in hospitalizations for CD in men aged from 0 to 39 years. A rising time trend for CD in women was observed between the years 2003 and 2007. The hospitalization rate for UC was higher in men (9.18 to 23.29 per 100,000) than in women (8.77 to 19.37 per 100,000). Rising time trends for UC were observed in the years from 2003 to 2007 in all men and women except for those aged from 40 to 64 years., Conclusions: Hospitalization rates for IBD in Poland increased from 1991 to 1996 and from 2003 to 2007, with rising time trends in both sexes. For CD, the rising time trend in men was limited to younger age groups. The hospitalization rate for UC was significantly higher in men than in women.

According to animal studies pancreastatin (PST), a peptide that is secreted by numerous neroendocrine cells, inhibits insulin secretion and has a hyperglycaemic and glycogenolytic effect. However, physiologic role of PST in carbohydrate metabolism remains unclear. In order to determine the best stimulus of PST secretion, four different stimulations of GI tract were carried out in 10 healthy volunteers: oral glucose loading test, intravenous glucose loading test, intravenous glucagon infusion and standard meal loading test. Serum PST concentration was measured radioimmunologically at established intervals after each stimulation. It was found that either oral or intravenous glucose loading test do not increase serum PST concentration; intravenous glucagon infusion decreases serum PST concentration and a standard meal increases serum PST concentration.

Objective: 1. To find out the prevalence of gastroperesis and of accelerated gastric emptying in long-standing and recently diagnosed diabetic patients. 2. and to determine the relationship between the percentage of gastric retention of the test meal to the gastric symptoms, degree of metabolic control, cardiovascular autonomic neuropathy, and late diabetic complication., Research Design and Methods: We studied the gastric emptying of technetium labeled digestible solid test meal in 81 diabetic patients (51 long-standing and 30 recently diagnosed diabetic patients) and in 44 healthy controls. Diabetic patients were divided roto 2 groups according to the type and duration of diabetes. All patients were evaluated for gastric symptoms, glycemic control, peripheral neuropathy, retinopathy and cardiovascular autonomic neuropathy., Results: Delayed gastric emptying was found in 21 long-standing diabetic patients and in 3 recently diagnosed type 2 diabetic patients. Accelerated gastric emptying was found in 10 patients mainly recently diagnosed type 2 diabetic patients. The rate of gastric emptying was related to CANP but not gastric symptoms or actual glycemic control., Conclusions: 1. Diabetics gastroparesis is a common disorder affecting both type 1 and type 2 long-standing diabetes mellitus in about 40% usually in the setting of late diabetic complications and can be manifested in recently diagnosed type 2 diabetes mellitus. 2. Accelerated gastric emptying is another gastrointestinal disorder manifested in about 20% of recently diagnosed diabetic patients (maimy type 2) but can be present in long-standing diabetic patients. 3. The rate of gastric emptying is related to cardiovascular autonomic neuropathy but not to gastric symptoms or actual metabolic control.