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Your search keyword '"Moi, Meng Ling"' showing total 7 results
Start Over Author "Moi, Meng Ling" Publisher microbiology society
7 results on '"Moi, Meng Ling"'

1. A single amino acid substitution in the NS4B protein of Dengue virus confers enhanced virus growth and fitness in human cells in vitro through IFN-dependent host response

Author

Bui, Thuy Thu, primary, Moi, Meng Ling, additional, Nabeshima, Takeshi, additional, Takemura, Taichiro, additional, Nguyen, Trang Thu, additional, Nguyen, Linh Ngoc, additional, Pham, Hang Thi Thu, additional, Nguyen, Thi Thu Thuy, additional, Manh, Dao Huy, additional, Dumre, Shyam Prakash, additional, Mizukami, Shusaku, additional, Hirayama, Kenji, additional, Tajima, Shigeru, additional, Le, Mai Thi Quynh, additional, Aoyagi, Kiyoshi, additional, Hasebe, Futoshi, additional, and Morita, Kouichi, additional

Published
2018
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2. Marmosets (Callithrix jacchus) as a non-human primate model for evaluation of candidate dengue vaccines: induction and maintenance of specific protective immunity against challenges with clinical isolates

Author

Moi, Meng Ling, primary, Ami, Yasushi, additional, Muhammad Azami, Nor Azila, additional, Shirai, Kenji, additional, Yoksan, Sutee, additional, Suzaki, Yuriko, additional, Kitaura, Kazutaka, additional, Lim, Chang-Kweng, additional, Saijo, Masayuki, additional, Suzuki, Ryuji, additional, Takasaki, Tomohiko, additional, and Kurane, Ichiro, additional

Published
2017
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5. Demonstration of marmosets (Callithrix jacchus) as a non-human primate model for secondary dengue virus infection: high levels of viraemia and serotype cross-reactive antibody responses consistent with secondary infection of humans

Author

Moi, Meng Ling, primary, Takasaki, Tomohiko, additional, Omatsu, Tsutomu, additional, Nakamura, Shinichiro, additional, Katakai, Yuko, additional, Ami, Yasushi, additional, Suzaki, Yuriko, additional, Saijo, Masayuki, additional, Akari, Hirofumi, additional, and Kurane, Ichiro, additional

Published
2014
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6. Common marmoset (Callithrix jacchus) as a primate model of dengue virus infection: development of high levels of viraemia and demonstration of protective immunity

Author

Omatsu, Tsutomu, primary, Moi, Meng Ling, additional, Hirayama, Takanori, additional, Takasaki, Tomohiko, additional, Nakamura, Shinichiro, additional, Tajima, Shigeru, additional, Ito, Mikako, additional, Yoshida, Tomoyuki, additional, Saito, Akatsuki, additional, Katakai, Yuko, additional, Akari, Hirofumi, additional, and Kurane, Ichiro, additional

Published
2011
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7. Involvement of the Fc gamma receptor IIA cytoplasmic domain in antibody-dependent enhancement of dengue virus infection.

Author

Moi ML, Lim CK, Takasaki T, and Kurane I

Subjects
Amino Acid Sequence, Animals, COS Cells, Chlorocebus aethiops, Humans, Molecular Sequence Data, Mutation, Receptors, IgG genetics, Antibody-Dependent Enhancement, Dengue Virus immunology, Dengue Virus pathogenicity, Receptors, IgG immunology
Abstract

Sub-neutralizing concentrations of antibody to dengue virus (DENV) enhance DENV infection of Fc gamma receptor-expressing cells. This phenomenon, referred to as antibody-dependent enhancement (ADE), has been hypothesized to be responsible for the severe form of DENV infection, including dengue haemorrhagic fever and dengue shock syndrome. To analyse further the mechanisms of ADE in vitro, this study introduced a series of cytoplasmic mutants into human Fc gammaRIIA. The mutated Fc gammaRIIA was then expressed on COS-7 cells to see whether these mutants could enhance DENV infection. Wild-type Fc gammaRIIA enhanced DENV infection, consistent with previous reports using Fc gammaR-positive monocytes. Disruption of the immune tyrosine activation motif (ITAM) in the cytoplasmic domain of Fc gammaRIIA or removing the sequences between the two ITAM regions eliminated ADE. These findings suggest that the specific structure of the Fc gammaRIIA cytoplasmic domain is essential for the ability of Fc gammaRIIA to mediate ADE.

Published
2010
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