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Your search keyword '"Sanglard, Dominique"' showing total 10 results
Start Over Author "Sanglard, Dominique" Publisher microbiology society
10 results on '"Sanglard, Dominique"'

10. Divergent functions of three Candida albicans zinc-cluster transcription factors (CTA4, ASG1 and CTF1) complementing pleiotropic drug resistance in Saccharomyces cerevisiae.

Author

Caste, Alix T., Ramsdale, Mark, Ischer, Françoise, and Sanglard, Dominique

Subjects
*CANDIDA albicans, *TRANSCRIPTION factors, *NUCLEAR receptors (Biochemistry), *SACCHAROMYCES cerevisiae, *GENE silencing, *GENETIC regulation, *GENE expression, *GENETIC translation, *CANDIDA, *ZINC
Abstract

The article offers information on the role of three Candida albicans zinc-cluster transcription factors, including CTA4, ASG1 and CTF1, complementing pleiotropic drug resistance in Saccharomyces cerevisiae. A study was conducted to determine the functional homologues of transcription factors in Candida albicans. ABC-transporter gene PDR5 is one of the mediators of pleiotropic drug resistance in Saccharomyces cerevisiae. Three zinc-cluster transcription factors, namely CTA4, ASG1 and CTF1, were identified. It is revealed that C. albicans possesses functional homologues of the S,. cerevisiae Pdr1p and Pdr3p transcription factors. The properties of three transcription factors have been rewired to other functions.

Published
2008
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