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Your search keyword '"Rodriguez, Alina"' showing total 16 results
Start Over Author "Rodriguez, Alina" Publisher mittuniversitetet, avdelningen for psykologi
16 results on '"Rodriguez, Alina"'

1. Different Risk Factors Between Disruptive Behavior Disorders and ADHD in Northern Finland Birth Cohort 1986

Author

Nordström, Tanja, Hurtig, Tuula, Rodriguez, Alina, Savolainen, Jukka, Rautio, Arja, Moilanen, Irma, Taanila, Anja, Ebeling, Hanna, Nordström, Tanja, Hurtig, Tuula, Rodriguez, Alina, Savolainen, Jukka, Rautio, Arja, Moilanen, Irma, Taanila, Anja, and Ebeling, Hanna

Abstract

Objective: To examine different risk factors between disruptive behavior disorders (DBD) and ADHD or combined DBD and ADHD. Method: The study population was derived from the Northern Finland Birth Cohort 1986. Psychiatric diagnoses were defined from the Schedule for Affective Disorders and Schizophrenia for School-Age Children–Present and Lifetime Version (K-SADS-PL) interview. The study sample was divided into four groups—people with DBD (n = 44), with ADHD (n = 91), with both (n = 72), and without either (n = 250)—to evaluate the different risk factors behind these disorders. Results: After adjusting with possible confounding factors, female gender and paternal admittance to inpatient psychiatric care increased the odds that an adolescent was having DBD. Childhood hyperactivity symptoms increased the odds of having ADHD and childhood hyperactivity symptoms and scholastic impairment increased the odds of having both disorders. Conclusion: Our study indicates DBD and ADHD have clearly different risk factors, and the impact of the paternal factors on DBD should be noted more than has been before., First Published July 7, 2014

Published
2017
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2. Guidelines for identification and treatment of individuals with attention deficit/hyperactivity disorder and associated fetal alcohol spectrum disorders based upon expert consensus

Author

Young, Susan, Absoud, Michael, Blackburn, Carolyn, Branney, Polly, Colley, Bill, Farrag, Emad, Fleisher, Susan, Gregory, Ges, Gudjonsson, Gisli H., Kim, Keira, O'Malley, Kieran D., Plant, Moira, Rodriguez, Alina, Ozer, Susan, Takon, Inyang, Woodhouse, Emma, Mukherjee, Raja, Young, Susan, Absoud, Michael, Blackburn, Carolyn, Branney, Polly, Colley, Bill, Farrag, Emad, Fleisher, Susan, Gregory, Ges, Gudjonsson, Gisli H., Kim, Keira, O'Malley, Kieran D., Plant, Moira, Rodriguez, Alina, Ozer, Susan, Takon, Inyang, Woodhouse, Emma, and Mukherjee, Raja

Abstract

Background: The association of attention deficit/hyperactivity disorder (ADHD) and fetal alcohol spectrum disorders (FASD) results in a complex constellation of symptoms that complicates the successful diagnosis and treatment of the affected individual. Current literature lacks formal guidelines, randomized control trials, and evidence-based treatment plans for individuals with ADHD and associated FASD. Therefore, a meeting of professional experts was organized with the aim of producing a consensus on identification and treatment guidelines that will aid clinicians in caring for this unique patient population. Methods: Experts from multiple disciplines in the fields of ADHD and FASD convened in London, United Kingdom, for a meeting hosted by the United Kingdom ADHD Partnership (UKAP; www.UKADHD.com) in June 2015. The meeting provided the opportunity to address the complexities of ADHD and FASD from different perspectives and included presentations, discussions, and group work. The attendees worked towards producing a consensus for a unified approach to ADHD and associated FASD. Results: The authors successfully came to consensus and produced recommended guidelines with specific regards to identification and assessment, interventions and treatments, and multiagency liaisons and care management, highlighting that a lifespan approach to treatment needs to be adopted by all involved. Included in the guidelines are: 1) unique 'red flags', which when identified in the ADHD population can lead to an accurate associated FASD diagnosis, 2) a treatment decision tree, and 3) recommendations for multiagency care management. Conclusions: While clinically useful guidelines were achieved, more research is still needed to contribute to the knowledge base about the diagnosis, treatment, and management of those with ADHD and associated FASD.

Published
2016
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3. Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013 : Findings From the Global Burden of Disease 2013 Study.

Author

Kyu, Hmwe H, Pinho, Christine, Wagner, Joseph A, Brown, Jonathan C, Bertozzi-Villa, Amelia, Charlson, Fiona J, Coffeng, Luc Edgar, Dandona, Lalit, Erskine, Holly E, Ferrari, Alize J, Fitzmaurice, Christina, Fleming, Thomas D, Forouzanfar, Mohammad H, Graetz, Nicholas, Guinovart, Caterina, Haagsma, Juanita, Higashi, Hideki, Kassebaum, Nicholas J, Larson, Heidi J, Lim, Stephen S, Mokdad, Ali H, Moradi-Lakeh, Maziar, Odell, Shaun V, Roth, Gregory A, Serina, Peter T, Stanaway, Jeffrey D, Misganaw, Awoke, Whiteford, Harvey A, Wolock, Timothy M, Wulf Hanson, Sarah, Abd-Allah, Foad, Abera, Semaw Ferede, Abu-Raddad, Laith J, AlBuhairan, Fadia S, Amare, Azmeraw T, Antonio, Carl Abelardo T, Artaman, Al, Barker-Collo, Suzanne L, Barrero, Lope H, Benjet, Corina, Bensenor, Isabela M, Bhutta, Zulfiqar A, Bikbov, Boris, Brazinova, Alexandra, Campos-Nonato, Ismael, Castañeda-Orjuela, Carlos A, Catalá-López, Ferrán, Chowdhury, Rajiv, Cooper, Cyrus, Crump, John A, Dandona, Rakhi, Degenhardt, Louisa, Dellavalle, Robert P, Dharmaratne, Samath D, Faraon, Emerito Jose A, Feigin, Valery L, Fürst, Thomas, Geleijnse, Johanna M, Gessner, Bradford D, Gibney, Katherine B, Goto, Atsushi, Gunnell, David, Hankey, Graeme J, Hay, Roderick J, Hornberger, John C, Hosgood, H Dean, Hu, Guoqing, Jacobsen, Kathryn H, Jayaraman, Sudha P, Jeemon, Panniyammakal, Jonas, Jost B, Karch, André, Kim, Daniel, Kim, Sungroul, Kokubo, Yoshihiro, Kuate Defo, Barthelemy, Kucuk Bicer, Burcu, Kumar, G Anil, Larsson, Anders, Leasher, Janet L, Leung, Ricky, Li, Yongmei, Lipshultz, Steven E, Lopez, Alan D, Lotufo, Paulo A, Lunevicius, Raimundas, Lyons, Ronan A, Majdan, Marek, Malekzadeh, Reza, Mashal, Taufiq, Mason-Jones, Amanda J, Melaku, Yohannes Adama, Memish, Ziad A, Mendoza, Walter, Miller, Ted R, Mock, Charles N, Murray, Joseph, Nolte, Sandra, Oh, In-Hwan, Olusanya, Bolajoko Olubukunola, Ortblad, Katrina F, Park, Eun-Kee, Paternina Caicedo, Angel J, Patten, Scott B, Patton, George C, Pereira, David M, Perico, Norberto, Piel, Frédéric B, Polinder, Suzanne, Popova, Svetlana, Pourmalek, Farshad, Quistberg, D Alex, Remuzzi, Giuseppe, Rodriguez, Alina, Rojas-Rueda, David, Rothenbacher, Dietrich, Rothstein, David H, Sanabria, Juan, Santos, Itamar S, Schwebel, David C, Sepanlou, Sadaf G, Shaheen, Amira, Shiri, Rahman, Shiue, Ivy, Skirbekk, Vegard, Sliwa, Karen, Sreeramareddy, Chandrashekhar T, Stein, Dan J, Steiner, Timothy J, Stovner, Lars Jacob, Sykes, Bryan L, Tabb, Karen M, Terkawi, Abdullah Sulieman, Thomson, Alan J, Thorne-Lyman, Andrew L, Towbin, Jeffrey Allen, Ukwaja, Kingsley Nnanna, Vasankari, Tommi, Venketasubramanian, Narayanaswamy, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Weiderpass, Elisabete, Weintraub, Robert G, Werdecker, Andrea, Wilkinson, James D, Woldeyohannes, Solomon Meseret, Wolfe, Charles D A, Yano, Yuichiro, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z, Yu, Chuanhua, El Sayed Zaki, Maysaa, Naghavi, Mohsen, Murray, Christopher J L, Vos, Theo, Kyu, Hmwe H, Pinho, Christine, Wagner, Joseph A, Brown, Jonathan C, Bertozzi-Villa, Amelia, Charlson, Fiona J, Coffeng, Luc Edgar, Dandona, Lalit, Erskine, Holly E, Ferrari, Alize J, Fitzmaurice, Christina, Fleming, Thomas D, Forouzanfar, Mohammad H, Graetz, Nicholas, Guinovart, Caterina, Haagsma, Juanita, Higashi, Hideki, Kassebaum, Nicholas J, Larson, Heidi J, Lim, Stephen S, Mokdad, Ali H, Moradi-Lakeh, Maziar, Odell, Shaun V, Roth, Gregory A, Serina, Peter T, Stanaway, Jeffrey D, Misganaw, Awoke, Whiteford, Harvey A, Wolock, Timothy M, Wulf Hanson, Sarah, Abd-Allah, Foad, Abera, Semaw Ferede, Abu-Raddad, Laith J, AlBuhairan, Fadia S, Amare, Azmeraw T, Antonio, Carl Abelardo T, Artaman, Al, Barker-Collo, Suzanne L, Barrero, Lope H, Benjet, Corina, Bensenor, Isabela M, Bhutta, Zulfiqar A, Bikbov, Boris, Brazinova, Alexandra, Campos-Nonato, Ismael, Castañeda-Orjuela, Carlos A, Catalá-López, Ferrán, Chowdhury, Rajiv, Cooper, Cyrus, Crump, John A, Dandona, Rakhi, Degenhardt, Louisa, Dellavalle, Robert P, Dharmaratne, Samath D, Faraon, Emerito Jose A, Feigin, Valery L, Fürst, Thomas, Geleijnse, Johanna M, Gessner, Bradford D, Gibney, Katherine B, Goto, Atsushi, Gunnell, David, Hankey, Graeme J, Hay, Roderick J, Hornberger, John C, Hosgood, H Dean, Hu, Guoqing, Jacobsen, Kathryn H, Jayaraman, Sudha P, Jeemon, Panniyammakal, Jonas, Jost B, Karch, André, Kim, Daniel, Kim, Sungroul, Kokubo, Yoshihiro, Kuate Defo, Barthelemy, Kucuk Bicer, Burcu, Kumar, G Anil, Larsson, Anders, Leasher, Janet L, Leung, Ricky, Li, Yongmei, Lipshultz, Steven E, Lopez, Alan D, Lotufo, Paulo A, Lunevicius, Raimundas, Lyons, Ronan A, Majdan, Marek, Malekzadeh, Reza, Mashal, Taufiq, Mason-Jones, Amanda J, Melaku, Yohannes Adama, Memish, Ziad A, Mendoza, Walter, Miller, Ted R, Mock, Charles N, Murray, Joseph, Nolte, Sandra, Oh, In-Hwan, Olusanya, Bolajoko Olubukunola, Ortblad, Katrina F, Park, Eun-Kee, Paternina Caicedo, Angel J, Patten, Scott B, Patton, George C, Pereira, David M, Perico, Norberto, Piel, Frédéric B, Polinder, Suzanne, Popova, Svetlana, Pourmalek, Farshad, Quistberg, D Alex, Remuzzi, Giuseppe, Rodriguez, Alina, Rojas-Rueda, David, Rothenbacher, Dietrich, Rothstein, David H, Sanabria, Juan, Santos, Itamar S, Schwebel, David C, Sepanlou, Sadaf G, Shaheen, Amira, Shiri, Rahman, Shiue, Ivy, Skirbekk, Vegard, Sliwa, Karen, Sreeramareddy, Chandrashekhar T, Stein, Dan J, Steiner, Timothy J, Stovner, Lars Jacob, Sykes, Bryan L, Tabb, Karen M, Terkawi, Abdullah Sulieman, Thomson, Alan J, Thorne-Lyman, Andrew L, Towbin, Jeffrey Allen, Ukwaja, Kingsley Nnanna, Vasankari, Tommi, Venketasubramanian, Narayanaswamy, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Weiderpass, Elisabete, Weintraub, Robert G, Werdecker, Andrea, Wilkinson, James D, Woldeyohannes, Solomon Meseret, Wolfe, Charles D A, Yano, Yuichiro, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z, Yu, Chuanhua, El Sayed Zaki, Maysaa, Naghavi, Mohsen, Murray, Christopher J L, and Vos, Theo

Abstract

IMPORTANCE: The literature focuses on mortality among children younger than 5 years. Comparable information on nonfatal health outcomes among these children and the fatal and nonfatal burden of diseases and injuries among older children and adolescents is scarce. OBJECTIVE: To determine levels and trends in the fatal and nonfatal burden of diseases and injuries among younger children (aged <5 years), older children (aged 5-9 years), and adolescents (aged 10-19 years) between 1990 and 2013 in 188 countries from the Global Burden of Disease (GBD) 2013 study. EVIDENCE REVIEW: Data from vital registration, verbal autopsy studies, maternal and child death surveillance, and other sources covering 14 244 site-years (ie, years of cause of death data by geography) from 1980 through 2013 were used to estimate cause-specific mortality. Data from 35 620 epidemiological sources were used to estimate the prevalence of the diseases and sequelae in the GBD 2013 study. Cause-specific mortality for most causes was estimated using the Cause of Death Ensemble Model strategy. For some infectious diseases (eg, HIV infection/AIDS, measles, hepatitis B) where the disease process is complex or the cause of death data were insufficient or unavailable, we used natural history models. For most nonfatal health outcomes, DisMod-MR 2.0, a Bayesian metaregression tool, was used to meta-analyze the epidemiological data to generate prevalence estimates. FINDINGS: Of the 7.7 (95% uncertainty interval [UI], 7.4-8.1) million deaths among children and adolescents globally in 2013, 6.28 million occurred among younger children, 0.48 million among older children, and 0.97 million among adolescents. In 2013, the leading causes of death were lower respiratory tract infections among younger children (905 059 deaths; 95% UI, 810 304-998 125), diarrheal diseases among older children (38 325 deaths; 95% UI, 30 365-47 678), and road injuries among adolescents (115 186 deaths; 95% UI, 105 185-124 870). Iron def, Group author: Global Burden of Disease Pediatrics Collaboration

Published
2016
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4. Common variation near ​ROBO2 is associated with expressive vocabulary in infancy

Author

St Pourcain, Beate and Rodriguez, Alina

Subjects
Psykologi, Psychology
Abstract

Twin studies suggest that expressive vocabulary at ~24 months is modestly heritable. However, the genes influencing this early linguistic phenotype are unknown. Here we conduct a genome-wide screen and follow-up study of expressive vocabulary in toddlers of European descent from up to four studies of the EArly Genetics and Lifecourse Epidemiology consortium, analysing an early (15–18 months, ‘one-word stage’, NTotal=8,889) and a later (24–30 months, ‘two-word stage’,NTotal=10,819) phase of language acquisition. For the early phase, one single-nucleotide polymorphism (rs7642482) at 3p12.3 near ​ROBO2, encoding a conserved axon-binding receptor, reaches the genome-wide significance level (P=1.3 × 10−8) in the combined sample. This association links language-related common genetic variation in the general population to a potential autism susceptibility locus and a linkage region for dyslexia, speech-sound disorder and reading. The contribution of common genetic influences is, although modest, supported by genome-wide complex trait analysis (meta-GCTA h215–18-months=0.13, meta-GCTA h224–30-months=0.14) and in concordance with additional twin analysis (5,733 pairs of European descent,h224-months=0.20).

Published
2014

5. Changes in health in England, with analysis by English regions and areas of deprivation, 1990-2013 : A systematic analysis for the Global Burden of Disease Study 2013

Author

Newton, J. N., Briggs, A. D. M., Murray, C. J. L., Dicker, D., Foreman, K. J., Wang, H., Naghavi, M., Forouzanfar, M. H., Ohno, S. L., Barber, R. M., Vos, T., Stanaway, J. D., Schmidt, J. C., Hughes, A. J., Fay, D. F. J., Ecob, R., Gresser, C., McKee, M., Rutter, H., Abubakar, I., Ali, R., Anderson, H. R., Banerjee, A., Bennett, D. A., Bernabé, E., Bhui, K. S., Biryukov, S. M., Bourne, R. R., Brayne, C. E. G., Bruce, N. G., Brugha, T. S., Burch, M., Capewell, S., Casey, D., Chowdhury, R., Coates, M. M., Cooper, C., Critchley, J. A., Dargan, P. I., Dherani, M. K., Elliott, P., Ezzati, M., Fenton, K. A., Fraser, M. S., Fürst, T., Greaves, F., Green, M. A., Gunnell, D. J., Hannigan, B. M., Hay, R. J., Hay, S. I., Hemingway, H., Larson, H. J., Looker, K. J., Lunevicius, R., Lyons, R. A., Marcenes, W., Mason-Jones, A. J., Matthews, F. E., Moller, H., Murdoch, M. E., Newton, C. R., Pearce, N., Piel, F. B., Pope, D., Rahimi, K., Rodriguez, Alina, Scarborough, P., Schumacher, A. E., Shiue, I., Smeeth, L., Tedstone, A., Valabhji, J., Williams, H. C., Wolfe, C. D. A., Woolf, A. D., Davis, A. C. J., Newton, J. N., Briggs, A. D. M., Murray, C. J. L., Dicker, D., Foreman, K. J., Wang, H., Naghavi, M., Forouzanfar, M. H., Ohno, S. L., Barber, R. M., Vos, T., Stanaway, J. D., Schmidt, J. C., Hughes, A. J., Fay, D. F. J., Ecob, R., Gresser, C., McKee, M., Rutter, H., Abubakar, I., Ali, R., Anderson, H. R., Banerjee, A., Bennett, D. A., Bernabé, E., Bhui, K. S., Biryukov, S. M., Bourne, R. R., Brayne, C. E. G., Bruce, N. G., Brugha, T. S., Burch, M., Capewell, S., Casey, D., Chowdhury, R., Coates, M. M., Cooper, C., Critchley, J. A., Dargan, P. I., Dherani, M. K., Elliott, P., Ezzati, M., Fenton, K. A., Fraser, M. S., Fürst, T., Greaves, F., Green, M. A., Gunnell, D. J., Hannigan, B. M., Hay, R. J., Hay, S. I., Hemingway, H., Larson, H. J., Looker, K. J., Lunevicius, R., Lyons, R. A., Marcenes, W., Mason-Jones, A. J., Matthews, F. E., Moller, H., Murdoch, M. E., Newton, C. R., Pearce, N., Piel, F. B., Pope, D., Rahimi, K., Rodriguez, Alina, Scarborough, P., Schumacher, A. E., Shiue, I., Smeeth, L., Tedstone, A., Valabhji, J., Williams, H. C., Wolfe, C. D. A., Woolf, A. D., and Davis, A. C. J.

Abstract

Background In the Global Burden of Disease Study 2013 (GBD 2013), knowledge about health and its determinants has been integrated into a comparable framework to inform health policy. Outputs of this analysis are relevant to current policy questions in England and elsewhere, particularly on health inequalities. We use GBD 2013 data on mortality and causes of death, and disease and injury incidence and prevalence to analyse the burden of disease and injury in England as a whole, in English regions, and within each English region by deprivation quintile. We also assess disease and injury burden in England attributable to potentially preventable risk factors. England and the English regions are compared with the remaining constituent countries of the UK and with comparable countries in the European Union (EU) and beyond. Methods We extracted data from the GBD 2013 to compare mortality, causes of death, years of life lost (YLLs), years lived with a disability (YLDs), and disability-adjusted life-years (DALYs) in England, the UK, and 18 other countries (the first 15 EU members [apart from the UK] and Australia, Canada, Norway, and the USA [EU15+]). We extended elements of the analysis to English regions, and subregional areas defined by deprivation quintile (deprivation areas). We used data split by the nine English regions (corresponding to the European boundaries of the Nomenclature for Territorial Statistics level 1 [NUTS 1] regions), and by quintile groups within each English region according to deprivation, thereby making 45 regional deprivation areas. Deprivation quintiles were defined by area of residence ranked at national level by Index of Multiple Deprivation score, 2010. Burden due to various risk factors is described for England using new GBD methodology to estimate independent and overlapping attributable risk for five tiers of behavioural, metabolic, and environmental risk factors. We present results for 306 causes and 2337 sequelae, and 79 risks or risk clu, Export Date: 21 December 2015 CODEN: LANCA Correspondence Address: Newton, J.N.; Public Health England, Wellington HouseUnited Kingdom; email: john.newton@phe.gov.uk References: Murray C.J.L., Richards M.A., Newton J.N., UK health performance: Findings of the Global Burden of Disease Study 2010 (2013) Lancet, 381, pp. 997-1020; Greer S.L., Devolution and divergence in UK health policies (2008) BMJ, 337, p. a2616; England N.H.S., (2014) Five Year Forward View, , http://www.england.nhs.uk/ourwork/futurenhs/, (accessed Aug 24, 2015); Naghavi M., Wang H., Lozano R., Global, regional and national levels of age-specific mortality and 240 causes of death, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013 (2015) Lancet, 385, pp. 117-171; Global, regional, and national incidence, prevalence, and years lived with disabilities for 301 acute and chronic diseases and injuries for 188 countries, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013 (2015) Lancet, 386, pp. 743-800; Global, regional, and national comparative risk assessment of 76 behavioural, environmental, occupational, and metabolic risks or clusters of risks in 188 countries 1990-2013: A systematic analysis for the Global Burden of Disease study 2013 (2015) Lancet, , http://dx.doi.org/10.1016/S0140-6736(15)00128-2, published online Sept 11; Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: Quantifying the epidemiological transition (2015) Lancet, , http://dx.doi.org/10.1016/S0140-6736(15)61340-X, published online Aug 27; Vos T., Flaxman A.D., Naghavi M., Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010 (2012) Lancet, 380, pp. 2163-2196; Murray C.J.L., Ezzati M., Flaxman A.D., GBD 2010: Design, definitions, and metrics (2012) Lancet, 380, p

Published
2015
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6. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013 : a systematic analysis for the Global Burden of Disease Study 2013.

Author

Forouzanfar, Mohammad H, Alexander, Lily, Anderson, H Ross, Bachman, Victoria F, Biryukov, Stan, Brauer, Michael, Burnett, Richard, Casey, Daniel, Coates, Matthew M, Cohen, Aaron, Delwiche, Kristen, Estep, Kara, Frostad, Joseph J, Astha, K C, Kyu, Hmwe H, Moradi-Lakeh, Maziar, Ng, Marie, Slepak, Erica Leigh, Thomas, Bernadette A, Wagner, Joseph, Aasvang, Gunn Marit, Abbafati, Cristiana, Abbasoglu Ozgoren, Ayse, Abd-Allah, Foad, Abera, Semaw F, Aboyans, Victor, Abraham, Biju, Abraham, Jerry Puthenpurakal, Abubakar, Ibrahim, Abu-Rmeileh, Niveen M E, Aburto, Tania C, Achoki, Tom, Adelekan, Ademola, Adofo, Koranteng, Adou, Arsène K, Adsuar, José C, Afshin, Ashkan, Agardh, Emilie E, Al Khabouri, Mazin J, Al Lami, Faris H, Alam, Sayed Saidul, Alasfoor, Deena, Albittar, Mohammed I, Alegretti, Miguel A, Aleman, Alicia V, Alemu, Zewdie A, Alfonso-Cristancho, Rafael, Alhabib, Samia, Ali, Raghib, Ali, Mohammed K, Alla, François, Allebeck, Peter, Allen, Peter J, Alsharif, Ubai, Alvarez, Elena, Alvis-Guzman, Nelson, Amankwaa, Adansi A, Amare, Azmeraw T, Ameh, Emmanuel A, Ameli, Omid, Amini, Heresh, Ammar, Walid, Anderson, Benjamin O, Antonio, Carl Abelardo T, Anwari, Palwasha, Argeseanu Cunningham, Solveig, Arnlöv, Johan, Arsenijevic, Valentina S Arsic, Artaman, Al, Asghar, Rana J, Assadi, Reza, Atkins, Lydia S, Atkinson, Charles, Avila, Marco A, Awuah, Baffour, Badawi, Alaa, Bahit, Maria C, Bakfalouni, Talal, Balakrishnan, Kalpana, Balalla, Shivanthi, Balu, Ravi Kumar, Banerjee, Amitava, Barber, Ryan M, Barker-Collo, Suzanne L, Barquera, Simon, Barregard, Lars, Barrero, Lope H, Barrientos-Gutierrez, Tonatiuh, Basto-Abreu, Ana C, Basu, Arindam, Basu, Sanjay, Basulaiman, Mohammed O, Batis Ruvalcaba, Carolina, Beardsley, Justin, Bedi, Neeraj, Bekele, Tolesa, Bell, Michelle L, Benjet, Corina, Bennett, Derrick A, Benzian, Habib, Bernabé, Eduardo, Beyene, Tariku J, Bhala, Neeraj, Bhalla, Ashish, Bhutta, Zulfiqar A, Bikbov, Boris, Bin Abdulhak, Aref A, Blore, Jed D, Blyth, Fiona M, Bohensky, Megan A, Bora Başara, Berrak, Borges, Guilherme, Bornstein, Natan M, Bose, Dipan, Boufous, Soufiane, Bourne, Rupert R, Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J, Brenner, Hermann, Briggs, Adam D M, Broday, David M, Brooks, Peter M, Bruce, Nigel G, Brugha, Traolach S, Brunekreef, Bert, Buchbinder, Rachelle, Bui, Linh N, Bukhman, Gene, Bulloch, Andrew G, Burch, Michael, Burney, Peter G J, Campos-Nonato, Ismael R, Campuzano, Julio C, Cantoral, Alejandra J, Caravanos, Jack, Cárdenas, Rosario, Cardis, Elisabeth, Carpenter, David O, Caso, Valeria, Castañeda-Orjuela, Carlos A, Castro, Ruben E, Catalá-López, Ferrán, Cavalleri, Fiorella, Çavlin, Alanur, Chadha, Vineet K, Chang, Jung-Chen, Charlson, Fiona J, Chen, Honglei, Chen, Wanqing, Chen, Zhengming, Chiang, Peggy P, Chimed-Ochir, Odgerel, Chowdhury, Rajiv, Christophi, Costas A, Chuang, Ting-Wu, Chugh, Sumeet S, Cirillo, Massimo, Claßen, Thomas K D, Colistro, Valentina, Colomar, Mercedes, Colquhoun, Samantha M, Contreras, Alejandra G, Cooper, Cyrus, Cooperrider, Kimberly, Cooper, Leslie T, Coresh, Josef, Courville, Karen J, Criqui, Michael H, Cuevas-Nasu, Lucia, Damsere-Derry, James, Danawi, Hadi, Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I, Davis, Adrian, Davitoiu, Dragos V, Dayama, Anand, de Castro, E Filipa, De la Cruz-Góngora, Vanessa, De Leo, Diego, de Lima, Graça, Degenhardt, Louisa, del Pozo-Cruz, Borja, Dellavalle, Robert P, Deribe, Kebede, Derrett, Sarah, Des Jarlais, Don C, Dessalegn, Muluken, deVeber, Gabrielle A, Devries, Karen M, Dharmaratne, Samath D, Dherani, Mukesh K, Dicker, Daniel, Ding, Eric L, Dokova, Klara, Dorsey, E Ray, Driscoll, Tim R, Duan, Leilei, Durrani, Adnan M, Ebel, Beth E, Ellenbogen, Richard G, Elshrek, Yousef M, Endres, Matthias, Ermakov, Sergey P, Erskine, Holly E, Eshrati, Babak, Esteghamati, Alireza, Fahimi, Saman, Faraon, Emerito Jose A, Farzadfar, Farshad, Fay, Derek F J, Feigin, Valery L, Feigl, Andrea B, Fereshtehnejad, Seyed-Mohammad, Ferrari, 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Lindsay, M Patrice, Lipshultz, Steven E, Liu, Shiwei, Liu, Yang, Lloyd, Belinda K, Logroscino, Giancarlo, London, Stephanie J, Lopez, Nancy, Lortet-Tieulent, Joannie, Lotufo, Paulo A, Lozano, Rafael, Lunevicius, Raimundas, Ma, Jixiang, Ma, Stefan, Machado, Vasco M P, MacIntyre, Michael F, Magis-Rodriguez, Carlos, Mahdi, Abbas A, Majdan, Marek, Malekzadeh, Reza, Mangalam, Srikanth, Mapoma, Christopher C, Marape, Marape, Marcenes, Wagner, Margolis, David J, Margono, Christopher, Marks, Guy B, Martin, Randall V, Marzan, Melvin B, Mashal, Mohammad T, Masiye, Felix, Mason-Jones, Amanda J, Matsushita, Kunihiro, Matzopoulos, Richard, Mayosi, Bongani M, Mazorodze, Tasara T, McKay, Abigail C, McKee, Martin, McLain, Abigail, Meaney, Peter A, Medina, Catalina, Mehndiratta, Man Mohan, Mejia-Rodriguez, Fabiola, Mekonnen, Wubegzier, Melaku, Yohannes A, Meltzer, Michele, Memish, Ziad A, Mendoza, Walter, Mensah, George A, Meretoja, Atte, Mhimbira, Francis Apolinary, Micha, Renata, Miller, Ted R, Mills, Edward J, Misganaw, Awoke, Mishra, Santosh, Mohamed Ibrahim, Norlinah, Mohammad, Karzan A, Mokdad, Ali H, Mola, Glen L, Monasta, Lorenzo, Montañez Hernandez, Julio C, Montico, Marcella, Moore, Ami R, Morawska, Lidia, Mori, Rintaro, Moschandreas, Joanna, Moturi, Wilkister N, Mozaffarian, Dariush, Mueller, Ulrich O, Mukaigawara, Mitsuru, Mullany, Erin C, Murthy, Kinnari S, Naghavi, Mohsen, Nahas, Ziad, Naheed, Aliya, Naidoo, Kovin S, Naldi, Luigi, Nand, Devina, Nangia, Vinay, Narayan, K M Venkat, Nash, Denis, Neal, Bruce, Nejjari, Chakib, Neupane, Sudan P, Newton, Charles R, Ngalesoni, Frida N, Ngirabega, Jean de Dieu, Nguyen, Grant, Nguyen, Nhung T, Nieuwenhuijsen, Mark J, Nisar, Muhammad I, Nogueira, José R, Nolla, Joan M, Nolte, Sandra, Norheim, Ole F, Norman, Rosana E, Norrving, Bo, Nyakarahuka, Luke, Oh, In-Hwan, Ohkubo, Takayoshi, Olusanya, Bolajoko O, Omer, Saad B, Opio, John Nelson, Orozco, Ricardo, Pagcatipunan, Rodolfo S, Pain, Amanda W, Pandian, Jeyaraj D, Panelo, Carlo Irwin A, Papachristou, Christina, Park, Eun-Kee, Parry, Charles D, Paternina Caicedo, Angel J, Patten, Scott B, Paul, Vinod K, Pavlin, Boris I, Pearce, Neil, Pedraza, Lilia S, Pedroza, Andrea, Pejin Stokic, Ljiljana, Pekericli, Ayfer, Pereira, David M, Perez-Padilla, Rogelio, Perez-Ruiz, Fernando, Perico, Norberto, Perry, Samuel A L, Pervaiz, Aslam, Pesudovs, Konrad, Peterson, Carrie B, Petzold, Max, Phillips, Michael R, Phua, Hwee Pin, Plass, Dietrich, Poenaru, Dan, Polanczyk, Guilherme V, Polinder, Suzanne, Pond, Constance D, Pope, C Arden, Pope, Daniel, Popova, Svetlana, Pourmalek, Farshad, Powles, John, Prabhakaran, Dorairaj, Prasad, Noela M, Qato, Dima M, Quezada, Amado D, Quistberg, D Alex A, Racapé, Lionel, Rafay, Anwar, Rahimi, Kazem, Rahimi-Movaghar, Vafa, Rahman, Sajjad Ur, Raju, Murugesan, Rakovac, Ivo, Rana, Saleem M, Rao, Mayuree, Razavi, Homie, Reddy, K Srinath, Refaat, Amany H, Rehm, Jürgen, Remuzzi, Giuseppe, Ribeiro, Antonio L, Riccio, Patricia M, Richardson, Lee, Riederer, Anne, Robinson, Margaret, Roca, Anna, Rodriguez, Alina, Rojas-Rueda, David, Romieu, Isabelle, Ronfani, Luca, Room, Robin, Roy, Nobhojit, Ruhago, George M, Rushton, Lesley, Sabin, Nsanzimana, Sacco, Ralph L, Saha, Sukanta, Sahathevan, Ramesh, Sahraian, Mohammad Ali, Salomon, Joshua A, Salvo, Deborah, Sampson, Uchechukwu K, Sanabria, Juan R, Sanchez, Luz Maria, Sánchez-Pimienta, Tania G, Sanchez-Riera, Lidia, Sandar, Logan, Santos, Itamar S, Sapkota, Amir, Satpathy, Maheswar, Saunders, James E, Sawhney, Monika, Saylan, Mete I, Scarborough, Peter, Schmidt, Jürgen C, Schneider, Ione J C, Schöttker, Ben, Schwebel, David C, Scott, James G, Seedat, Soraya, Sepanlou, Sadaf G, Serdar, Berrin, Servan-Mori, Edson E, Shaddick, Gavin, Shahraz, Saeid, Levy, Teresa Shamah, Shangguan, Siyi, She, Jun, Sheikhbahaei, Sara, Shibuya, Kenji, Shin, Hwashin H, Shinohara, Yukito, Shiri, Rahman, Shishani, Kawkab, Shiue, Ivy, Sigfusdottir, Inga D, Silberberg, Donald H, Simard, Edgar P, Sindi, Shireen, Singh, Abhishek, Singh, Gitanjali M, Singh, Jasvinder A, Skirbekk, Vegard, Sliwa, Karen, Soljak, Michael, Soneji, Samir, Søreide, Kjetil, Soshnikov, Sergey, Sposato, Luciano A, Sreeramareddy, Chandrashekhar T, Stapelberg, Nicolas J C, Stathopoulou, Vasiliki, Steckling, Nadine, Stein, Dan J, Stein, Murray B, Stephens, Natalie, Stöckl, Heidi, Straif, Kurt, Stroumpoulis, Konstantinos, Sturua, Lela, Sunguya, Bruno F, Swaminathan, Soumya, Swaroop, Mamta, Sykes, Bryan L, Tabb, Karen M, Takahashi, Ken, Talongwa, Roberto T, Tandon, Nikhil, Tanne, David, Tanner, Marcel, Tavakkoli, Mohammad, Te Ao, Braden J, Teixeira, Carolina M, Téllez Rojo, Martha M, Terkawi, Abdullah S, Texcalac-Sangrador, José Luis, Thackway, Sarah V, Thomson, Blake, Thorne-Lyman, Andrew L, Thrift, Amanda G, Thurston, George D, Tillmann, Taavi, Tobollik, Myriam, Tonelli, Marcello, Topouzis, Fotis, Towbin, Jeffrey A, Toyoshima, Hideaki, Traebert, Jefferson, Tran, Bach X, Trasande, Leonardo, Trillini, Matias, Trujillo, Ulises, Dimbuene, Zacharie Tsala, Tsilimbaris, Miltiadis, Tuzcu, Emin Murat, Uchendu, Uche S, Ukwaja, Kingsley N, Uzun, Selen B, van de Vijver, Steven, Van Dingenen, Rita, van Gool, Coen H, van Os, Jim, Varakin, Yuri Y, Vasankari, Tommi J, Vasconcelos, Ana Maria N, Vavilala, Monica S, Veerman, Lennert J, Velasquez-Melendez, Gustavo, Venketasubramanian, N, Vijayakumar, Lakshmi, Villalpando, Salvador, Violante, Francesco S, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Wagner, Gregory R, Waller, Stephen G, Wallin, Mitchell T, Wan, Xia, Wang, Haidong, Wang, JianLi, Wang, Linhong, Wang, Wenzhi, Wang, Yanping, Warouw, Tati S, Watts, Charlotte H, Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G, Werdecker, Andrea, Wessells, K Ryan, Westerman, Ronny, Whiteford, Harvey A, Wilkinson, James D, Williams, Hywel C, Williams, Thomas N, Woldeyohannes, Solomon M, Wolfe, Charles D A, Wong, John Q, Woolf, Anthony D, Wright, Jonathan L, Wurtz, Brittany, Xu, Gelin, Yan, Lijing L, Yang, Gonghuan, Yano, Yuichiro, Ye, Pengpeng, Yenesew, Muluken, Yentür, Gökalp K, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z, Younoussi, Zourkaleini, Yu, Chuanhua, Zaki, Maysaa E, Zhao, Yong, Zheng, Yingfeng, Zhou, Maigeng, Zhu, Jun, Zhu, Shankuan, Zou, Xiaonong, Zunt, Joseph R, Lopez, Alan D, Vos, Theo, and Murray, Christopher J

Abstract

BACKGROUND: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution. METHODS: Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk-outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990-2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the first level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular filtration rate. For most risks, data for exposure were synthesised with a Bayesian meta-regression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol. FINDINGS: All risks combined account for 57·2%

Published
2015
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7. A novel common variant in DCST2 is associated with length in early life and height in adulthood

Author

van der Valk, Ralf J P, Kreiner-Møller, Eskil, Kooijman, Marjolein N, Guxens, Mònica, Stergiakouli, Evangelia, Sääf, Annika, Bradfield, Jonathan P, Geller, Frank, Hayes, M Geoffrey, Cousminer, Diana L, Körner, Antje, Thiering, Elisabeth, Curtin, John A, Myhre, Ronny, Huikari, Ville, Joro, Raimo, Kerkhof, Marjan, Warrington, Nicole M, Pitkänen, Niina, Ntalla, Ioanna, Horikoshi, Momoko, Veijola, Riitta, Freathy, Rachel M, Teo, Yik-Ying, Barton, Sheila J, Evans, David M, Kemp, John P, St Pourcain, Beate, Ring, Susan M, Davey Smith, George, Bergström, Anna, Kull, Inger, Hakonarson, Hakon, Mentch, Frank D, Bisgaard, Hans, Chawes, Bo, Stokholm, Jakob, Waage, Johannes, Eriksen, Patrick, Sevelsted, Astrid, Melbye, Mads, van Duijn, Cornelia M, Medina-Gomez, Carolina, Hofman, Albert, de Jongste, Johan C, Taal, H Rob, Uitterlinden, André G, Armstrong, Loren L, Eriksson, Johan, Palotie, Aarno, Bustamante, Mariona, Estivill, Xavier, Gonzalez, Juan R, Llop, Sabrina, Kiess, Wieland, Mahajan, Anubha, Flexeder, Claudia, Tiesler, Carla M T, Murray, Clare S, Simpson, Angela, Magnus, Per, Sengpiel, Verena, Hartikainen, Anna-Liisa, Keinanen-Kiukaanniemi, Sirkka, Lewin, Alexandra, Da Silva Couto Alves, Alexessander, Blakemore, Alexandra I, Buxton, Jessica L, Kaakinen, Marika, Rodriguez, Alina, Sebert, Sylvain, Vaarasmaki, Marja, Lakka, Timo, Lindi, Virpi, Gehring, Ulrike, Postma, Dirkje S, Ang, Wei, Newnham, John P, Lyytikäinen, Leo-Pekka, Pahkala, Katja, Raitakari, Olli T, Panoutsopoulou, Kalliope, Zeggini, Eleftheria, Boomsma, Dorret I, Groen-Blokhuis, Maria, Ilonen, Jorma, Franke, Lude, Hirschhorn, Joel N, Pers, Tune H, Liang, Liming, Huang, Jinyan, Hocher, Berthold, Knip, Mikael, Saw, Seang-Mei, Holloway, John W, Melén, Erik, Grant, Struan F A, Feenstra, Bjarke, Lowe, William L, Widén, Elisabeth, Sergeyev, Elena, Grallert, Harald, Custovic, Adnan, Jacobsson, Bo, Jarvelin, Marjo-Riitta, Atalay, Mustafa, Koppelman, Gerard H, Pennell, Craig E, Niinikoski, Harri, Dedoussis, George V, Mccarthy, Mark I, Frayling, Timothy M, Sunyer, Jordi, Timpson, Nicholas J, Rivadeneira, Fernando, Bønnelykke, Klaus, Jaddoe, Vincent W V, van der Valk, Ralf J P, Kreiner-Møller, Eskil, Kooijman, Marjolein N, Guxens, Mònica, Stergiakouli, Evangelia, Sääf, Annika, Bradfield, Jonathan P, Geller, Frank, Hayes, M Geoffrey, Cousminer, Diana L, Körner, Antje, Thiering, Elisabeth, Curtin, John A, Myhre, Ronny, Huikari, Ville, Joro, Raimo, Kerkhof, Marjan, Warrington, Nicole M, Pitkänen, Niina, Ntalla, Ioanna, Horikoshi, Momoko, Veijola, Riitta, Freathy, Rachel M, Teo, Yik-Ying, Barton, Sheila J, Evans, David M, Kemp, John P, St Pourcain, Beate, Ring, Susan M, Davey Smith, George, Bergström, Anna, Kull, Inger, Hakonarson, Hakon, Mentch, Frank D, Bisgaard, Hans, Chawes, Bo, Stokholm, Jakob, Waage, Johannes, Eriksen, Patrick, Sevelsted, Astrid, Melbye, Mads, van Duijn, Cornelia M, Medina-Gomez, Carolina, Hofman, Albert, de Jongste, Johan C, Taal, H Rob, Uitterlinden, André G, Armstrong, Loren L, Eriksson, Johan, Palotie, Aarno, Bustamante, Mariona, Estivill, Xavier, Gonzalez, Juan R, Llop, Sabrina, Kiess, Wieland, Mahajan, Anubha, Flexeder, Claudia, Tiesler, Carla M T, Murray, Clare S, Simpson, Angela, Magnus, Per, Sengpiel, Verena, Hartikainen, Anna-Liisa, Keinanen-Kiukaanniemi, Sirkka, Lewin, Alexandra, Da Silva Couto Alves, Alexessander, Blakemore, Alexandra I, Buxton, Jessica L, Kaakinen, Marika, Rodriguez, Alina, Sebert, Sylvain, Vaarasmaki, Marja, Lakka, Timo, Lindi, Virpi, Gehring, Ulrike, Postma, Dirkje S, Ang, Wei, Newnham, John P, Lyytikäinen, Leo-Pekka, Pahkala, Katja, Raitakari, Olli T, Panoutsopoulou, Kalliope, Zeggini, Eleftheria, Boomsma, Dorret I, Groen-Blokhuis, Maria, Ilonen, Jorma, Franke, Lude, Hirschhorn, Joel N, Pers, Tune H, Liang, Liming, Huang, Jinyan, Hocher, Berthold, Knip, Mikael, Saw, Seang-Mei, Holloway, John W, Melén, Erik, Grant, Struan F A, Feenstra, Bjarke, Lowe, William L, Widén, Elisabeth, Sergeyev, Elena, Grallert, Harald, Custovic, Adnan, Jacobsson, Bo, Jarvelin, Marjo-Riitta, Atalay, Mustafa, Koppelman, Gerard H, Pennell, Craig E, Niinikoski, Harri, Dedoussis, George V, Mccarthy, Mark I, Frayling, Timothy M, Sunyer, Jordi, Timpson, Nicholas J, Rivadeneira, Fernando, Bønnelykke, Klaus, and Jaddoe, Vincent W V

Abstract

Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 × 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; β = 0.046, SE = 0.008, P = 2.46 × 10(-8), explained variance = 0.05%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 × 10(-4)) and adult height (N = 127 513; P = 1.45 × 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13% of variance in birth length. The same SNPs explained 2.95% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height.

Published
2015
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8. Prevalence of purging at age 16 and associations with negative outcomes among girls in three community-based cohorts.

Author

Solmi, Francesca, Sonneville, Kendrin R, Easter, Abigail, Horton, Nicholas J, Crosby, Ross D, Treasure, Janet, Rodriguez, Alina, Jarvelin, Marjo-Riitta, Field, Alison E, Micali, Nadia, Solmi, Francesca, Sonneville, Kendrin R, Easter, Abigail, Horton, Nicholas J, Crosby, Ross D, Treasure, Janet, Rodriguez, Alina, Jarvelin, Marjo-Riitta, Field, Alison E, and Micali, Nadia

Abstract

BACKGROUND: The comorbidity of purging behaviours, such as vomiting, inappropriate use of laxatives, diuretics or slimming medications, has been examined in literature. However, most studies do not include adolescents, individuals who purge in the absence of binge eating, or those purging at subclinical frequency. This study examines the prevalence of purging among 16-year-old girls across three countries and their association with substance use and psychological comorbidity. METHODS: Data were obtained by questionnaire in 3 population-based cohorts (Avon Longitudinal Study of Parents and Children (ALSPAC), United Kingdom, n = 1,608; Growing Up Today Study (GUTS), USA, n = 3,504; North Finland Birth Cohort (NFBC85/86), Finland, n = 2,306). Multivariate logistic regressions were employed to estimate associations between purging and outcomes. Four models were fit adjusting for binge eating and potential confounders of these associations. RESULTS: In ALSPAC, 9.7% of girls reported purging in the 12-months prior to assessment, 7.3% in GUTS, and 3.5% in NFBC. In all 3 cohorts, purging was associated with adverse outcomes such as binge drinking (ALSPAC: odds ratio (OR) = 2.0, 95% confidence interval (CI) = 1.4-2.9; GUTS: OR = 2.5, 95% CI = 1.5-4.0; NFBC: OR = 1.7, 95% CI = 1.0-2.8), drug use (ALSPAC: OR = 2.9, 95% CI = 1.8-4.7; GUTS: OR = 4.5, 95% CI = 2.8-7.3; NFBC: OR = 4.1, 95% CI = 2.6-6.6), depressive symptoms in ALSPAC (OR = 2.2, 95% CI = 1.5-3.1) and GUTS(OR = 3.7, 95% CI = 2.2-6.3), and several psychopathology measures including clinical anxiety/depression in NFBC (OR = 11.2, 95% CI = 3.9, 31.7). CONCLUSIONS: Results show a higher prevalence of purging behaviours among girls in the United Kingdom compared to those in the United States and Finland. Our findings support evidence highlighting that purging in adolescence is associated with negative outcomes, independent of its frequency and binge eating.

Published
2015
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9. Slip of the tongue : Implications for evolution and language development

Author

Forrester, Gillian S., Rodriguez, Alina, Forrester, Gillian S., and Rodriguez, Alina

Abstract

A prevailing theory regarding the evolution of language implicates a gestural stage prior to the emergence of speech. In support of a transition of human language from a gestural to a vocal system, articulation of the hands and the tongue are underpinned by overlapping left hemisphere dominant neural regions. Behavioral studies demonstrate that human adults perform sympathetic mouth actions in imitative synchrony with manual actions. Additionally, right-handedness for precision manual actions in children has been correlated with the typical development of language, while a lack of hand bias has been associated with psychopathology. It therefore stands to reason that sympathetic mouth actions during fine precision motor action of the hands may be lateralized. We employed a fine-grained behavioral coding paradigm to provide the first investigation of tongue protrusions in typically developing 4-year old children. Tongue protrusions were investigated across a range of cognitive tasks that required varying degrees of manual action: precision motor action, gross motor action and no motor actions. The rate of tongue protrusions was influenced by the motor requirements of the task and tongue protrusions were significantly right-biased for only precision manual motor action (p < .001). From an evolutionary perspective, tongue protrusions can drive new investigations regarding how an early human communication system transitioned from hand to mouth. From a developmental perspective, the present study may serve to reveal patterns of tongue protrusions during the motor development of typically developing children. (C) 2015 Elsevier B.V. All rights reserved.

Published
2015
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11. Infant locomotive development and its association with adult blood pressure.

Author

Pillas, Demetris, Kaakinen, Marika, Tzoulaki, Ioanna, Netuveli, Gopalakrishnan, Rodriguez, Alina, Fung, Erik, Tammelin, Tuija H, Blane, David, Millwood, Iona Y, Hardy, Rebecca, Sovio, Ulla, Pouta, Anneli, Hopstock, Laila Arnesdatter, Hartikainen, Anna-Liisa, Laitinen, Jaana, Vaara, Sarianna, Khan, Anokhi Ali, Chong, Raymond, Elliott, Paul, Jarvelin, Marjo-Riitta, Pillas, Demetris, Kaakinen, Marika, Tzoulaki, Ioanna, Netuveli, Gopalakrishnan, Rodriguez, Alina, Fung, Erik, Tammelin, Tuija H, Blane, David, Millwood, Iona Y, Hardy, Rebecca, Sovio, Ulla, Pouta, Anneli, Hopstock, Laila Arnesdatter, Hartikainen, Anna-Liisa, Laitinen, Jaana, Vaara, Sarianna, Khan, Anokhi Ali, Chong, Raymond, Elliott, Paul, and Jarvelin, Marjo-Riitta

Abstract

UNLABELLED: Evidence from animal models suggests that locomotion and blood pressure share common neurophysiological regulatory systems. As a result of this common regulation, we hypothesized that the development of locomotion in human infants would be associated with blood pressure levels in adulthood. The study sample comprised 4,347 individuals with measures of locomotive and non-locomotive neuromotor development in infancy and adult blood pressure levels within a longitudinal birth cohort study, the Northern Finland Birth Cohort 1966. Later development in all three stages of locomotive development during infancy was associated with higher systolic and diastolic blood pressure levels at age 31. For age of walking without support, 0.34 (95 % CI 0.07 to 0.60)-mm Hg higher SBP and 0.38 (95 % CI 0.15 to 0.62)-mm Hg higher DBP were estimated for each month of later achievement (P = 0.012 for SBP; P = 0.001 for DBP). No association was identified for non-locomotive neuromotor development. CONCLUSION: These results highlight the positive sequelae of advanced locomotive development during infancy, suggesting that the common regulatory systems between locomotion and blood pressure may influence the development of raised blood pressure over time.

Published
2014
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12. Maternal pre-pregnancy body mass index and offspring attention deficit hyperactivity disorder : a population-based cohort study using a sibling-comparison design

Author

Chen, Qi, Sjölander, Arvid, Långström, Niklas, Rodriguez, Alina, Serlachius, Eva, D'Onofrio, Brian M., Lichtenstein, Paul, Larsson, Henrik, Chen, Qi, Sjölander, Arvid, Långström, Niklas, Rodriguez, Alina, Serlachius, Eva, D'Onofrio, Brian M., Lichtenstein, Paul, and Larsson, Henrik

Abstract

Methods We conducted a population-based cohort study via linkage of Swedish national and regional registers to investigate maternal pre-pregnancy BMI (underweight: BMI < 18.5; overweight: 25 BMI < 30; obesity: BMI epsilon 30) in relation to offspring ADHD. We followed 673 632 individuals born in Sweden between 1992 and 2000, with prospectively collected information on maternal pre-pregnancy BMI, until they received an ADHD diagnosis or ADHD medication, death, emigration or 31 December 2009. Hazard ratios (HRs) were estimated by Cox proportional hazards models. Stratified Cox proportional hazards models were applied to data on full siblings to control for unmeasured familial confounding. Results At the population level, pre-pregnancy overweight/obesity was associated with increased risk of offspring ADHD (HRoverweight = 1.23, 95% CI = 1.18-1.27, P = 0.01; HRobesity = 1.64, 95% CI = 1.57-1.73, P = 0.01), after adjustment for measured covariates. In full sibling comparisons, however, previously observed associations no longer remained (HRoverweight = 0.98, 95% CI = 0.83-1.16, P = 0.82; HRobesity = 1.15, 95% CI = 0.85-1.56, P = 0.38). Conclusions The results suggested that the association between maternal pre-pregnancy overweight/obesity and offspring ADHD could be ascribed to unmeasured familial confounding.

Published
2014
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13. Multiple Measures of Adiposity Are Associated with Mean Leukocyte Telomere Length in the Northern Finland Birth Cohort 1966

Author

Buxton, Jessica L., Das, Shikta, Rodriguez, Alina, Kaakinen, Marika, Alves, Alexessander Couto, Sebert, Sylvain, Millwood, Iona Y., Laitinen, Jaana, O'Reilly, Paul F., Jarvelin, Marjo-Riitta, Blakemore, Alexandra I. F., Buxton, Jessica L., Das, Shikta, Rodriguez, Alina, Kaakinen, Marika, Alves, Alexessander Couto, Sebert, Sylvain, Millwood, Iona Y., Laitinen, Jaana, O'Reilly, Paul F., Jarvelin, Marjo-Riitta, and Blakemore, Alexandra I. F.

Abstract

Studies of leukocyte telomere length (LTL) and adiposity have produced conflicting results, and the relationship between body mass index (BMI) and telomere length throughout life remains unclear. We therefore tested association of adult LTL measured in 5,598 participants with: i) childhood growth measures (BMI and age at adiposity rebound (AR)); ii) change in BMI from childhood to adulthood and iii) adult BMI, waist-to-hip ratio (WHR), body adiposity index (BAI). Childhood BMI at AR was positively associated with LTL at 31 years in women (P = 0.041). Adult BMI and WHR in both men (P = 0.025 and P = 0.049, respectively) and women (P = 0.029 and P = 0.008, respectively), and BAI in women (P = 0.021) were inversely associated with LTL at 31 years. An increase in standardised BMI between early childhood and adulthood was associated with shorter adult LTL in women (P = 0.008). We show that LTL is inversely associated with multiple measures of adiposity in both men and women. Additionally, BMI increase in women from childhood to adulthood is associated with shorter telomeres at age 31, potentially indicating accelerated biological ageing.

Published
2014
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14. Childhood Attention-Deficit/Hyperactivity Disorder Symptoms Are Risk Factors for Obesity and Physical Inactivity in Adolescence

Author

Khalife, Natasha, Kantomaa, Marko, Glover, Vivette, Tammelin, Tuija, Laitinen, Jaana, Ebeling, Hanna, Hurtig, Tuula, Jarvelin, Marjo-Riitta, Rodriguez, Alina, Khalife, Natasha, Kantomaa, Marko, Glover, Vivette, Tammelin, Tuija, Laitinen, Jaana, Ebeling, Hanna, Hurtig, Tuula, Jarvelin, Marjo-Riitta, and Rodriguez, Alina

Abstract

Objective: To prospectively investigate the association and directionality between attention-deficit/hyperactivity disorder (ADHD) symptoms and obesity from childhood to adolescence in the general population. We examined whether obesogenic behaviors, namely, physical inactivity and binge eating, underlie the potential ADHD symptom obesity association. We explored whether childhood conduct disorder (CD) symptoms are related to adolescent obesity/physical inactivity. Method: At 7 to 8 years (n = 8,106), teachers reported ADHD and CD symptoms, and parents reported body mass index (BMI) and physically active play. At 16 years (n = 6,934), parents reported ADHD symptoms; adolescents reported physical activity (transformed to metabolic equivalent of task [MET] hours per week) and binge eating; BMI and waist hip ratio (WHR) were measured via clinical examination. Obesity was defined using the International Obesity Task Force (IOTF) cut-offs for BMI and the 95th percentile cut-off for WHR. Results: Childhood ADHD symptoms significantly predicted adolescent obesity, rather than the opposite. Inattention-hyperactivity symptoms at 8 years were associated with indices of obesity at 16 years (obese BMI: odds ratio [OR] = 1.91, 95% confidence interval [CI] = 1.10-3.33; 95th percentile WHR: OR = 1.71, 95% CI = 1.05-2.78), adjusted for gender, baseline BMI, physical activity, family structure change, and maternal education. Child CD symptoms associated with indices of adolescent obesity. Reduced physically active play in childhood predicted adolescent inattention (OR = 1.61,95% CI = 1.16-2.24). Childhood ADHD and CD symptoms were linked with physical inactivity in adolescence (inattention-hyperactivity; OR = 1.60, 95% CI = 1.20-2.13), but not binge eating. Physical inactivity mediated the associations. Conclusions: Children with ADHD or CD symptoms are at increased risk for becoming obese and physically inactive adolescents. Physical activity may be beneficial for both behavior pro

Published
2014
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15. Prenatal Glucocorticoid Treatment and Later Mental Health in Children and Adolescents

Author

Khalife, Natasha, Glover, Vivette, Taanila, Anja, Ebeling, Hanna, Jarvelin, Marjo-Riitta, Rodriguez, Alina, Khalife, Natasha, Glover, Vivette, Taanila, Anja, Ebeling, Hanna, Jarvelin, Marjo-Riitta, and Rodriguez, Alina

Abstract

Background: Animal studies demonstrate a clear link between prenatal exposure to glucocorticoids (GC) and altered offspring brain development. We aim to examine whether prenatal GC exposure programs long-term mental health in humans. Methods: Using propensity-score-matching, children prenatally exposed to synthetic glucocorticoids (sGC), n=37, and controls, n=185, were balanced on important confounders related to sGC treatment - gestational age and pre-pregnancy BMI. We also used mixed-effects modeling to analyse the entire cohort - matching each sGC case, n=37, to all possible controls, n=6079, on gestational age and sex. We obtained data from the Northern Finland Birth Cohort 1986 at four waves - pregnancy, birth, 8 and 16 years. Data on pregnancy and birth outcomes came from medical records. Mental health was assessed at 8 years by teachers with the Rutter B2 scale, and at 16 years by parents with the Strengths and Weaknesses of ADHD symptoms and Normal behavior (SWAN) scale and adolescents by the Youth Self-Report (YSR) scale. Results: Prenatal sGC treatment was consistently associated with adverse mental health in childhood and adolescence, as shown by both the propensity-score method and mixed-effects model. Using the propensity-score-matched subsample, linear multiple regression showed prenatal sGC was significantly linked with general psychiatric disturbance (B=8.34 [95% CI: .23-16.45]) and inattention (B=.97 [95% CI:. 16-1.80]) at 8 years after control for relevant confounders. Similar findings were obtained at 16 years, but did not reach statistical significance. Mediation by birthweight/placental weight was not detected. Conclusions: This study is the first to prospectively investigate the long-term associations between prenatal exposure to sGC treatment and mental health in children and adolescents. We report an association between prenatal exposure to sGC and child mental health, supportive of the idea that sGC has a programming effect on the fetal brai

Published
2013
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16. Physical activity and obesity mediate the association between childhood motor function and adolescents' academic achievement

Author

Kantomaa, M. T., Stamatakis, E., Kankaanpää, A., Kaakinen, M., Rodriguez, Alina, Taanila, A., Ahonen, T., Järvelin, M. -R, Tammelin, T., Kantomaa, M. T., Stamatakis, E., Kankaanpää, A., Kaakinen, M., Rodriguez, Alina, Taanila, A., Ahonen, T., Järvelin, M. -R, and Tammelin, T.

Abstract

The global epidemic of obesity and physical inactivity may have detrimental implications for young people's cognitive function and academic achievement. This prospective study investigated whether childhood motor function predicts later academic achievement via physical activity, fitness, and obesity. The study sample included 8,061 children from the Northern Finland Birth Cohort 1986, which contains data about parent-reported motor function at age 8 y and self-reported physical activity, predicted cardiorespiratoryfitness (cycle ergometer test), obesity (body weight and height), and academic achievement (grades) at age 16 y. Structural equation models with unstandardized (B) and standardized (β) coefficients were used to test whether, and to what extent, physical activity, cardiorespiratory fitness, and obesity at age 16 mediated the association between childhood motor function and adolescents' academic achievement. Physical activity was associated with a higher grade-point average, and obesity was associated with a lower grade-point average in adolescence. Furthermore, compromised motor function in childhood had a negative indirect effect on adolescents' academic achievement via physical inactivity (B = -0.023, 95% confidence interval = -0.031, -0.015) and obesity (B = -0.025, 95% confidence interval = -0.039, -0.011), but not via cardiorespiratory fitness. These results suggest that physical activity and obesity may mediate the association between childhood motor function and adolescents' academic achievement. Compromised motorfunctioninchildhood may represent an important factor driving the effects of obesity and physical inactivity on academic underachievement., CODEN: PNASA

Published
2013
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