1. Ulcerative Colitis and Crohn’s Disease Are Associated with Decreased Serum Selenium Concentrations and Increased Cardiovascular Risk
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Cristina Sánchez, José Ángel Rufián-Henares, Miguel Navarro-Alarcón, Flor Nogueras-López, Javier Quesada Granados, Teresa Castro Aguilar-Tablada, [Castro Aguilar-Tablada, Teresa] Hosp Jerez de la Frontera, Digest Dept, E-11403 Cadiz, Spain, [Castro Aguilar-Tablada, Teresa] Univ Granada, Fac Pharm, Dept Nutr & Food Chem, E-18071 Granada, Spain, [Navarro-Alarcon, Miguel] Univ Granada, Fac Pharm, Dept Nutr & Food Chem, E-18071 Granada, Spain, [Quesada Granados, Javier] Univ Granada, Fac Pharm, Dept Nutr & Food Chem, E-18071 Granada, Spain, [Samaniego Sanchez, Cristina] Univ Granada, Fac Pharm, Dept Nutr & Food Chem, E-18071 Granada, Spain, [Angel Rufian-Henares, Jose] Univ Granada, Fac Pharm, Dept Nutr & Food Chem, E-18071 Granada, Spain, [Angel Rufian-Henares, Jose] Univ Granada, Inst Invest Biosanitaria IBS, E-18012 Granada, Spain, [Nogueras-Lopez, Flor] Granada Hosp Complex, Hepatol Dept, E-18012 Granada, Spain, Consejeriaw de Ciencia y Empresa (Junta de Andalucia), [Castro Aguilar-Tablada,T] Digestive Department, Hospital of Jerez de la Frontera, Cádiz, Spain. [Castro Aguilar-Tablada,T, Navarro-Alarcón,M, Quesada Granados,J, Samaniego Sánchez,C, Rufián-Henares,JA] Department of Nutrition and Food Chemistry, Faculty of Pharmacy, University of Granada, Granada, Spain. [Rufián-Henares,JA] Instituto de Investigación Biosanitaria (IBS), University of Granada, Granada, Spain. [Nogueras-Lopez,F] Hepatology Department, Granada Hospital Complex, Granada, Spain., and This study was financially supported by research funds from project AGR-141 from the Consejería de Ciencia y Empresa (Junta de Andalucía).
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Male ,Crohn’s disease ,Enfermedades inflamatorias del intestino ,Diseases::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Inflammatory Bowel Diseases::Crohn Disease [Medical Subject Headings] ,Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Hemoglobins [Medical Subject Headings] ,Expression ,Índice de masa corporal ,Hematocrit ,Severity of Illness Index ,Gastroenterology ,Inflammatory bowel disease ,Body Mass Index ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,0302 clinical medicine ,Health Transition ,Estado nutricional ,Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Nutritional Status [Medical Subject Headings] ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Hematologic Tests::Hematocrit [Medical Subject Headings] ,selenium ,Hematócrito ,Estrés oxidativo ,Ulcerative colitis ,Humanos ,Crohn's disease ,Cardiovascular Diseases ,Disease Progression ,Enfermedades cardiovasculares ,Colesterol ,lcsh:Nutrition. Foods and food supply ,Factores de riesgo ,medicine.medical_specialty ,Colon ,lcsh:TX341-641 ,influencing factors ,Hospitals, General ,Article ,03 medical and health sciences ,Diseases::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Colitis::Colitis, Ulcerative [Medical Subject Headings] ,Chemicals and Drugs::Inorganic Chemicals::Elements::Metals, Heavy::Iron [Medical Subject Headings] ,Inflammatory-bowel-disease ,Chemicals and Drugs::Biological Factors::Biological Markers [Medical Subject Headings] ,Humans ,Diseases::Cardiovascular Diseases [Medical Subject Headings] ,ulcerative colitis ,030109 nutrition & dietetics ,Macrophages ,Albumin ,nutritional and biochemical markers ,medicine.disease ,digestive system diseases ,Immunology ,Colitis, Ulcerative ,Hemoglobin ,Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation [Medical Subject Headings] ,Body mass index ,Biomarkers ,0301 basic medicine ,Antioxidantes ,medicine.disease_cause ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings] ,Diseases::Digestive System Diseases::Gastrointestinal Diseases::Intestinal Diseases::Inflammatory Bowel Diseases [Medical Subject Headings] ,Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants [Medical Subject Headings] ,Crohn Disease ,Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Carboxylic Ester Hydrolases::Cholinesterases [Medical Subject Headings] ,Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress [Medical Subject Headings] ,Nutrition and Dietetics ,medicine.diagnostic_test ,Prealbúmina ,Hemoglobinas ,Female ,Colinesterasas ,Incidencia ,Hierro ,Adult ,Risk ,Population ,Nutritional Status ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Mass Index [Medical Subject Headings] ,030209 endocrinology & metabolism ,Sex Factors ,Selenio ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence [Medical Subject Headings] ,Colitis ulcerosa ,Internal medicine ,medicine ,Obesity ,Enfermedad de Crohn ,Inflamación ,business.industry ,Chemicals and Drugs::Inorganic Chemicals::Elements::Chalcogens::Selenium [Medical Subject Headings] ,Malnutrition ,Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Albumins::Serum Albumin::Prealbumin [Medical Subject Headings] ,Chemicals and Drugs::Lipids::Sterols::Cholesterol [Medical Subject Headings] ,Biomarcadores ,Spain ,alpha 1-Antitrypsin ,Deficiency Diseases ,business ,Oxidative stress ,Food Science - Abstract
Journal Article; The incidence of inflammatory bowel disease (IBD) and associated oxidative stress is increasing. The antioxidant mineral selenium (Se) was measured in serum samples from 106 IBD patients (53 with ulcerative colitis (UC) and 53 with Crohn's disease (CD)) and from 30 healthy controls. Serum Se concentrations were significantly lower in UC and CD patients than in healthy controls (p < 0.001) and significantly lower in CD patients than in UC patients (p = 0.006). Se concentrations in patients were significantly influenced by sex, body mass index (BMI), the inflammatory biomarker α-1-antitrypsin, surgery, medical treatment, the severity, extent, and form of the disease and the length of time since onset (p < 0.05). Se concentrations in IBD patients were positively and linearly correlated with nutritional (protein, albumin, prealbumin, cholinesterase and total cholesterol) and iron status-related (hemoglobin, Fe and hematocrit) parameters (p < 0.05). A greater impairment of serum Se and cardiovascular status was observed in CD than in UC patients. An adequate nutritional Se status is important in IBD patients to minimize the cardiovascular risk associated with increased inflammation biomarkers, especially in undernourished CD patients, and is also related to an improved nutritional and body iron status. Yes
- Published
- 2016
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