1. Fabrication of Membrane Sensitive Electrodes for the Validated Electrochemical Quantification of Anti-Osteoporotic Drug Residues in Pharmaceutical Industrial Wastewater
- Author
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Sherif A. Abdel-Gawad, Abdulmalik M. Alqarni, Hany H. Arab, Obaid Afzal, and Alhumaidi B Alabbas
- Subjects
glassy carbon electrode ,Materials science ,Drug Industry ,Pharmaceutical Science ,Industrial Waste ,Organic chemistry ,Glassy carbon ,PVC-based membrane electrode ,Electrochemistry ,Article ,Analytical Chemistry ,Ion selective electrode ,Industrial wastewater treatment ,chemistry.chemical_compound ,QD241-441 ,Drug Discovery ,Physical and Theoretical Chemistry ,Polyvinyl Chloride ,Electrodes ,wastewater ,Chromatography ,Alendronate ,Reproducibility of Results ,Membranes, Artificial ,Electrochemical Techniques ,Hydrogen-Ion Concentration ,Carbon ,Drug Residues ,Polyvinyl chloride ,ion selective electrode ,Membrane ,Wastewater ,chemistry ,electrochemistry ,Chemistry (miscellaneous) ,Electrode ,Potentiometry ,Molecular Medicine ,Osteoporosis ,Glass - Abstract
Accurate and precise application of ion-selective electrodes (ISEs) in the quantification of environmental pollutants is a strenuous task. In this work, the electrochemical response of alendronate sodium trihydrate (ALN) was evaluated by the fabrication of two sensitive and delicate membrane electrodes, viz. polyvinyl chloride (PVC) and glassy carbon (GC) electrodes. A linear response was obtained at concentrations from 1 × 10−5 to 1 × 10−2 M for both electrodes. A Nernstian slope of 29 mV/decade over a pH range of 8–11 for the PVC and GC membrane electrodes was obtained. All assay settings were carefully adjusted to obtain the best electrochemical response. The proposed technique was effectively applied for the quantification of ALN in pure form and wastewater samples, acquired from manufacturing industries. The proposed electrodes were effectively used for the determination of ALN in real wastewater samples without any prior treatment. The current findings guarantee the applicability of the fabricated ISEs for the environmental monitoring of ALN.
- Published
- 2021
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