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Your search keyword '"Storer, Mekayla"' showing total 2 results
Start Over Author "Storer, Mekayla" Publisher national academy of sciences
2 results on '"Storer, Mekayla"'

1. Schwann cell precursors contribute to skeletal formation during embryonic development in mice and zebrafish.

Author

Meng Xie, Kamenev, Dmitrii, Kaucka, Marketa, Kastriti, Maria Eleni, Zhou, Baoyi, Artemov, Artem V., Storer, Mekayla, Fried, Kaj, Adameyko, Igor, Dyachuk, Vyacheslav, and Chagin, Andrei S.

Subjects
FISH embryology, SCHWANN cells, NEUROGLIA, CHROMAFFIN cells, NERVOUS system
Abstract

Immature multipotent embryonic peripheral glial cells, the Schwann cell precursors (SCPs), differentiate into melanocytes, parasympathetic neurons, chromaffin cells, and dental mesenchymal populations. Here, genetic lineage tracing revealed that, during murine embryonic development, some SCPs detach from nerve fibers to become mesenchymal cells, which differentiate further into chondrocytes and mature osteocytes. This occurred only during embryonic development, producing numerous craniofacial and trunk skeletal elements, without contributing to development of the appendicular skeleton. Formation of chondrocytes from SCPs also occurred in zebrafish, indicating evolutionary conservation. Our findings reveal multipotency of SCPs, providing a developmental link between the nervous system and skeleton. [ABSTRACT FROM AUTHOR]

Published
2019
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2. Schwann cell precursors contribute to skeletal formation during embryonic development in mice and zebrafish.

Author

Xie M, Kamenev D, Kaucka M, Kastriti ME, Zhou B, Artemov AV, Storer M, Fried K, Adameyko I, Dyachuk V, and Chagin AS

Subjects
Animals, Biomarkers metabolism, Bone and Bones embryology, Bone and Bones metabolism, Cell Differentiation, Chondrocytes metabolism, Chromaffin Cells cytology, Chromaffin Cells metabolism, Embryo, Mammalian, Embryo, Nonmammalian, Embryonic Development, Gene Expression, Melanocytes cytology, Melanocytes metabolism, Mesenchymal Stem Cells metabolism, Mice, Multipotent Stem Cells cytology, Multipotent Stem Cells metabolism, Myelin Proteolipid Protein genetics, Myelin Proteolipid Protein metabolism, Nerve Fibers metabolism, Nerve Tissue embryology, Nerve Tissue metabolism, Neural Crest cytology, Neural Crest growth & development, Neural Crest metabolism, Neural Stem Cells cytology, Neural Stem Cells metabolism, Neuroglia cytology, Neuroglia metabolism, Neurons cytology, Neurons metabolism, Osteocytes cytology, Osteocytes metabolism, SOXE Transcription Factors genetics, SOXE Transcription Factors metabolism, Schwann Cells metabolism, Zebrafish embryology, Zebrafish genetics, Zebrafish metabolism, Bone and Bones cytology, Cell Lineage genetics, Chondrocytes cytology, Mesenchymal Stem Cells cytology, Nerve Tissue cytology, Schwann Cells cytology
Abstract

Immature multipotent embryonic peripheral glial cells, the Schwann cell precursors (SCPs), differentiate into melanocytes, parasympathetic neurons, chromaffin cells, and dental mesenchymal populations. Here, genetic lineage tracing revealed that, during murine embryonic development, some SCPs detach from nerve fibers to become mesenchymal cells, which differentiate further into chondrocytes and mature osteocytes. This occurred only during embryonic development, producing numerous craniofacial and trunk skeletal elements, without contributing to development of the appendicular skeleton. Formation of chondrocytes from SCPs also occurred in zebrafish, indicating evolutionary conservation. Our findings reveal multipotency of SCPs, providing a developmental link between the nervous system and skeleton., Competing Interests: The authors declare no conflict of interest., (Copyright © 2019 the Author(s). Published by PNAS.)

Published
2019
Full Text
View/download PDF

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