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Your search keyword '"Toshihiro Imaeda"' showing total 1 results
Start Over Author "Toshihiro Imaeda" Publisher national academy of sciences
1 results on '"Toshihiro Imaeda"'

1. Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.

Author

Kirkman, Laura A., Wenhu Zhan, Visone, Joseph, Dziedziech, Alexis, Singh, Pradeep K., Hao Fan, Xinran Tong, Bruzual, Igor, Ryoma Hara, Masanori Kawasaki, Toshihiro Imaeda, Rei Okamoto, Kenjiro Sato, Mayako Michino, Alvaro, Elena Fernandez, Guiang, Liselle F., Sanz, Laura, Mota, Daniel J., Govindasamy, Kavitha, and Rong Wang

Subjects
PLASMODIUM falciparum, ASPARAGINE, ETHYLENEDIAMINE, PROTEASOMES, ANTIMALARIALS
Abstract

The article presents a study to describe noncovalent, reversible asparagine ethylenediamine (AsnEDA) inhibitors of the Plasmodium falciparum proteasome (Pf20S) beta-5 subunit that spare all active subunits of human constitutive and immuno-proteasomes. It identifies inhibitors with improved selectivity for malaria proteasome beta-5 subunit over each active subunit of human proteasomes.

Published
2018
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