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Your search keyword '"Wei Wei Shen"' showing total 2 results
Start Over Author "Wei Wei Shen" Publisher national academy of sciences
2 results on '"Wei Wei Shen"'

1. STIM1-induced precortical and cortical subdomains of the endoplasmic reticulum

Author

Orci, Lelio, Ravazzola, Mariella, Le Coadic, Marion, Wei-wei Shen, Demaurex, Nicolas, and Cosson, Pierre

Subjects
Endoplasmic reticulum -- Chemical properties, Science and technology
Abstract

Store-operated calcium entry relies on the formation of a specialized compartment derived from the endoplasmic reticulum (ER) and closely apposed to the plasma membrane. In this study, detailed ultrastructural analysis revealed the existence of three distinct structures derived from conventional ER: precortical ER, cortical ER, and thin cortical ER. Precortical subdomains of the ER enriched in STIM1 can form without contacting the plasma membrane. Upon ER calcium depletion, these subdomains are translocated to the plasma membrane to form cortical ER, which is still connected to the conventional ER. Thin cortical ER, depleted of BiP and deprived of attached ribosomes, may represent a specialized region dedicated to calcium regulation and not engaged in protein translocation and folding. These observations form the basis for future structure-function analysis of cortical ER. calcium | store-operated calcium entry www.pnas.org/cgi/doi/10.1073/pnas.0911280106

Published
2009

2. STIM1-induced precortical and cortical subdomains of the endoplasmic reticulum

Author

Pierre Cosson, Mariella Ravazzola, Marion Le Coadic, Nicolas Demaurex, Lelio Orci, and Wei-Wei Shen

Subjects
Calcium metabolism, Multidisciplinary, Endoplasmic reticulum, Compartment (ship), Cell Membrane, chemistry.chemical_element, Membrane Proteins, STIM1, Biology, Calcium, Biological Sciences, Endoplasmic Reticulum, Cell biology, Neoplasm Proteins, Cell membrane, medicine.anatomical_structure, Membrane protein, chemistry, medicine, Humans, Calcium Signaling, Stromal Interaction Molecule 1, Calcium signaling, HeLa Cells
Abstract

Store-operated calcium entry relies on the formation of a specialized compartment derived from the endoplasmic reticulum (ER) and closely apposed to the plasma membrane. In this study, detailed ultrastructural analysis revealed the existence of three distinct structures derived from conventional ER: precortical ER, cortical ER, and thin cortical ER. Precortical subdomains of the ER enriched in STIM1 can form without contacting the plasma membrane. Upon ER calcium depletion, these subdomains are translocated to the plasma membrane to form cortical ER, which is still connected to the conventional ER. Thin cortical ER, depleted of BiP and deprived of attached ribosomes, may represent a specialized region dedicated to calcium regulation and not engaged in protein translocation and folding. These observations form the basis for future structure-function analysis of cortical ER.

Published
2009

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