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Objective: To determine the current supply and demand for Amoxicillin 500 mg capsules at the pharmaceutical market level based on readily available and comparative data methods. Study Design: Cross-sectional. Place and Duration of Study: The study was carried out at hundred pharmacies spread throughout the three cities of Khartoum State (Khartoum, Omdurman, and Khartoum-North) from April 4, 2018 to June 17, 2018. Materials and Methods: A market survey was conducted by visiting 100 pharmacies and basic questions were posed directly to the pharmacist about the annual sale of Amoxicillin 500 mg capsules through a questionnaire. The data was analyzed using the consumption process, and the projected actual demand for amoxicillin 500 mg capsules up to the year 2027 in Sudanese markets was estimated. Results: The analyzed data showed a difference of about 756 million capsules between the current supply and real demand of 500 mg capsules of amoxicillin up to 2027. Moreover, the findings showed that there are substantial variations in annual sales of amoxicillin 500 mg capsules among the three cities where the survey was performed. Conclusion: The results of this study can be used as a guide for estimating the actual demands for Amoxicillin 500 mg capsules in the Sudanese pharmaceutical market for the future.