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Your search keyword '"Camilla Calandrini"' showing total 2 results
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2 results on '"Camilla Calandrini"'

1. Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours

Author

Lars Custers, Eleonora Khabirova, Tim H. H. Coorens, Thomas R. W. Oliver, Camilla Calandrini, Matthew D. Young, Felipe A. Vieira Braga, Peter Ellis, Lira Mamanova, Heidi Segers, Arie Maat, Marcel Kool, Eelco W. Hoving, Marry M. van den Heuvel-Eibrink, James Nicholson, Karin Straathof, Liz Hook, Ronald R. de Krijger, Claire Trayers, Kieren Allinson, Sam Behjati, and Jarno Drost

Subjects
Science
Abstract

Malignant rhabdoid tumours (MRT) have been suggested to originate in the ectoderm-derived neural crest. Here, the authors analyse MRTs using phylogenetics, scRNA-seq, and patient-derived organoids; they find evidence for an MRT origin in the neural crest lineage and suggest differentiation treatment with HDAC/mTOR inhibitors.

Published
2021
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2. An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity

Author

Camilla Calandrini, Frans Schutgens, Rurika Oka, Thanasis Margaritis, Tito Candelli, Luka Mathijsen, Carola Ammerlaan, Ravian L. van Ineveld, Sepide Derakhshan, Sanne de Haan, Emmy Dolman, Philip Lijnzaad, Lars Custers, Harry Begthel, Hindrik H. D. Kerstens, Lindy L. Visser, Maarten Rookmaaker, Marianne Verhaar, Godelieve A. M. Tytgat, Patrick Kemmeren, Ronald R. de Krijger, Reem Al-Saadi, Kathy Pritchard-Jones, Marcel Kool, Anne C. Rios, Marry M. van den Heuvel-Eibrink, Jan J. Molenaar, Ruben van Boxtel, Frank C. P. Holstege, Hans Clevers, and Jarno Drost

Subjects
Science
Abstract

Pre-clinical cell culture models capturing the heterogeneity of childhood kidney tumours are limited. Here, the authors establish and characterise an organoid biobank of tumour and matched normal organoid cultures from over 50 children with different subtypes of kidney cancer.

Published
2020
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