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1. Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2

Author

Masaki Takasugi, Ryo Okada, Akiko Takahashi, David Virya Chen, Sugiko Watanabe, and Eiji Hara

Subjects
Science
Abstract

Although senescent cell secretome can promote the growth of surrounding cancer cells, the role of extracellular vesicles in this process has not been well understood. Here the authors show that ROS increase the sorting of EphA2 into extracellular vesicles in senescent cells, which promotes proliferation of cancer cells.

Published
2017
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