Search

Your search keyword '"Jack S. Hardwick"' showing total 1 results
Start Over Author "Jack S. Hardwick" Publisher nature portfolio
1 results on '"Jack S. Hardwick"'

1. An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides

Author

Ysobel R. Baker, Cameron Thorpe, Jinfeng Chen, Laura M. Poller, Lina Cox, Pawan Kumar, Wooi F. Lim, Lillian Lie, Graham McClorey, Sven Epple, Daniel Singleton, Michael A. McDonough, Jack S. Hardwick, Kirsten E. Christensen, Matthew J. A. Wood, James P. Hall, Afaf H. El-Sagheer, and Tom Brown

Subjects
Science
Abstract

Oligonucleotides targeting mRNA are promising therapeutic agents but suffer from poor bioavailability. Here, the authors develop reduced-charge oligonucleotides with artificial LNA-amide linkages with improved cell uptake and minimal structural deviation to the DNA:RNA duplex.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results