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Conduction velocity and precise neuronal transmission depend on axonal diameter and ephatic coupling, respectively. Here, the authors showed that wrapping glia regulates both conduction speed and precision of neuronal signalling in the Drosophila peripheral nervous system.

In Drosophila, ensheathing glia encase the neuropil but their function is not well understood. Here the authors show a surprising role of ensheathing glia in regulating glutamate homeostasis and locomotion which is controlled by the sulfite oxidase Shopper.