Author: "Luke S. Howard" / Publisher: nature portfolio - Searchworks@Jio Institute Digital Library Search Results

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Start Over Author "Luke S. Howard" Publisher nature portfolio

Author: Anna Ulrich, Yukyee Wu, Harmen Draisma, John Wharton, Emilia M. Swietlik, Inês Cebola, Eleni Vasilaki, Zhanna Balkhiyarova, Marjo-Riitta Jarvelin, Juha Auvinen, Karl-Heinz Herzig, J. Gerry Coghlan, James Lordan, Colin Church, Luke S. Howard, Joanna Pepke-Zaba, Mark Toshner, Stephen J. Wort, David G. Kiely, Robin Condliffe, Allan Lawrie, Stefan Gräf, Nicholas W. Morrell, Martin R. Wilkins, Inga Prokopenko, and Christopher J. Rhodes
Subjects: Science
Abstract: Abstract Pulmonary arterial hypertension (PAH) is characterised by pulmonary vascular remodelling causing premature death from right heart failure. Established DNA variants influence PAH risk, but susceptibility from epigenetic changes is unknown. We addressed this through epigenome-wide association study (EWAS), testing 865,848 CpG sites for association with PAH in 429 individuals with PAH and 1226 controls. Three loci, at Cathepsin Z (CTSZ, cg04917472), Conserved oligomeric Golgi complex 6 (COG6, cg27396197), and Zinc Finger Protein 678 (ZNF678, cg03144189), reached epigenome-wide significance (p
Published: 2024
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Author: Alexander J. Ainscough, Timothy J. Smith, Maike Haensel, Christopher J. Rhodes, Adam Fellows, Harry J. Whitwell, Eleni Vasilaki, Kelly Gray, Adrian Freeman, Luke S. Howard, John Wharton, Benjamin Dunmore, Paul D. Upton, Martin R. Wilkins, Joshua B. Edel, and Beata Wojciak-Stothard
Subjects: Biology (General), QH301-705.5
Abstract: A biomimetic inducible model of pulmonary arterial hypertension (PAH) is presented, combining natural and induced BMPR2 dysfunction with hypoxia in lung endothelial cells and blood-derived PAH cells to induce smooth muscle activation & proliferation.
Published: 2022
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Author: Sokratis Kariotis, Emmanuel Jammeh, Emilia M. Swietlik, Josephine A. Pickworth, Christopher J. Rhodes, Pablo Otero, John Wharton, James Iremonger, Mark J. Dunning, Divya Pandya, Thomas S. Mascarenhas, Niamh Errington, A. A. Roger Thompson, Casey E. Romanoski, Franz Rischard, Joe G. N. Garcia, Jason X.-J. Yuan, Tae-Hwi Schwantes An, Ankit A. Desai, Gerry Coghlan, Jim Lordan, Paul A. Corris, Luke S. Howard, Robin Condliffe, David G. Kiely, Colin Church, Joanna Pepke-Zaba, Mark Toshner, Stephen Wort, Stefan Gräf, Nicholas W. Morrell, Martin R. Wilkins, Allan Lawrie, Dennis Wang, and UK National PAH Cohort Study Consortium
Subjects: Science
Abstract: Idiopathic pulmonary arterial hypertension is a rare and fatal disease with a heterogeneous treatment response. Here the authors show that unsupervised machine learning of whole blood transcriptomes from 359 patients with idiopathic pulmonary arterial hypertension identifies 3 subgroups (endophenotypes) that improve risk stratification and provide new molecular insights.
Published: 2021
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Author: Sokratis Kariotis, Emmanuel Jammeh, Emilia M. Swietlik, Josephine A. Pickworth, Christopher J. Rhodes, Pablo Otero, John Wharton, James Iremonger, Mark J. Dunning, Divya Pandya, Thomas S. Mascarenhas, Niamh Errington, A. A. Roger Thompson, Casey E. Romanoski, Franz Rischard, Joe G. N. Garcia, Jason X.-J. Yuan, Tae-Hwi Schwantes An, Ankit A. Desai, Gerry Coghlan, Jim Lordan, Paul A. Corris, Luke S. Howard, Robin Condliffe, David G. Kiely, Colin Church, Joanna Pepke-Zaba, Mark Toshner, Stephen Wort, Stefan Gräf, Nicholas W. Morrell, Martin R. Wilkins, Allan Lawrie, Dennis Wang, and UK National PAH Cohort Study Consortium
Subjects: Science
Published: 2022
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