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1. Unscheduled DNA replication in G1 causes genome instability and damage signatures indicative of replication collisions

Author

Karl-Uwe Reusswig, Julia Bittmann, Martina Peritore, Mathilde Courtes, Benjamin Pardo, Michael Wierer, Matthias Mann, and Boris Pfander

Subjects
Science
Abstract

Reusswig et al. use engineered systems to force DNA replication in the G1 phase of the cell cycle. This unscheduled G1 replication shows hallmarks of S phase replication, but leads to over-replication and DNA breaks from replication collisions.

Published
2022
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