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Abstract Mass antigen testing has been proposed as a possible cost-effective tool to contain the COVID-19 pandemic. We test the impact of a voluntary mass testing campaign implemented in the Italian region of South Tyrol on the spread of the virus in the following months. We do so by using an innovative empirical approach which embeds a semi-parametric growth model—where COVID-19 transmission dynamics are allowed to vary across regions and to be impacted by the implementation of the mass testing campaign—into a synthetic control framework which creates an appropriate control group of other Italian regions. Our results suggest that mass testing campaigns are useful instruments for mitigating the pandemic.