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1. Impact of the volume of the myelomeningocele sac on imaging, prenatal neurosurgery and motor outcomes: a retrospective cohort study

Author

Romain Corroenne, Amy R. Mehollin-Ray, Rebecca M. Johnson, William E. Whitehead, Jimmy Espinoza, Jonathan Castillo, Heidi Castillo, Gunes Orman, Roopali Donepudi, Thierry A. G. M. Huisman, Ahmed A. Nassr, Michael A. Belfort, Magdalena Sanz Cortes, and Alireza A. Shamshirsaz

Subjects
Medicine, Science
Abstract

Abstract To investigate the association of the myelomeningocele (MMC) volume with prenatal and postnatal motor function (MF) in cases who underwent a prenatal repair. Retrospective cohort study (11/2011 to 03/2019) of 63 patients who underwent a prenatal MMC repair (37 fetoscopic, 26 open-hysterotomy). At referral, measurements of the volume of MMC was performed based on ultrasound scans. A large MMC was defined as greater than the optimal volume threshold (ROC analysis) for the prediction of intact MF at referral (2.7 cc). Prenatal or postnatal intact motor function (S1) was defined as the observation of plantar flexion of the ankle based on ultrasound scan or postnatal examination. 23/63 participants presented a large MMC. Large MMC lesions was associated with an increased risk of having clubfeet by 9.5 times (CI%95[2.1–41.8], p

Published
2021
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2. Impact of the volume of the myelomeningocele sac on imaging, prenatal neurosurgery and motor outcomes: a retrospective cohort study

Author

William E. Whitehead, Roopali Donepudi, Thierry A.G.M. Huisman, Jonathan Castillo, Magdalena Sanz Cortes, Rebecca M Johnson, Jimmy Espinoza, Heidi Castillo, Romain Corroenne, Amy R. Mehollin-Ray, Gunes Orman, Alireza A. Shamshirsaz, Michael A. Belfort, and Ahmed A. Nassr

Subjects
Risk, medicine.medical_specialty, Meningomyelocele, Ultrasound scan, Science, Gestational Age, Paediatric research, Plantar flexion, Article, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, medicine, Humans, Fetal Movement, Encephalocele, Retrospective Studies, 030219 obstetrics & reproductive medicine, Multidisciplinary, Movement Disorders, Cerebrospinal Fluid Leak, business.industry, Fetoscopy, Ultrasound, Retrospective cohort study, Organ Size, Surgery, Clubfoot, Increased risk, medicine.anatomical_structure, Treatment Outcome, Outcomes research, Medicine, Female, Neurosurgery, Ankle, Hysterotomy, business, 030217 neurology & neurosurgery, Hydrocephalus
Abstract

To investigate the association of the myelomeningocele (MMC) volume with prenatal and postnatal motor function (MF) in cases who underwent a prenatal repair. Retrospective cohort study (11/2011 to 03/2019) of 63 patients who underwent a prenatal MMC repair (37 fetoscopic, 26 open-hysterotomy). At referral, measurements of the volume of MMC was performed based on ultrasound scans. A large MMC was defined as greater than the optimal volume threshold (ROC analysis) for the prediction of intact MF at referral (2.7 cc). Prenatal or postnatal intact motor function (S1) was defined as the observation of plantar flexion of the ankle based on ultrasound scan or postnatal examination. 23/63 participants presented a large MMC. Large MMC lesions was associated with an increased risk of having clubfeet by 9.5 times (CI%95[2.1–41.8], p Trial registration: Clinicaltrials.gov NCT02230072 and NCT03794011 registered on September 3rd, 2014 and January 4th, 2019.

Published
2021

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