Search

Your search keyword '"Salvatore Pulcrano"' showing total 1 results
Start Over Author "Salvatore Pulcrano" Publisher nature portfolio
Sorry, I don't understand your search. ×
1 results on '"Salvatore Pulcrano"'

1. Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders

Author

Maria De Risi, Michele Tufano, Filomena Grazia Alvino, Maria Grazia Ferraro, Giulia Torromino, Ylenia Gigante, Jlenia Monfregola, Elena Marrocco, Salvatore Pulcrano, Lea Tunisi, Claudia Lubrano, Dulce Papy-Garcia, Yaakov Tuchman, Alberto Salleo, Francesca Santoro, Gian Carlo Bellenchi, Luigia Cristino, Andrea Ballabio, Alessandro Fraldi, and Elvira De Leonibus

Subjects
Science
Abstract

Lysosomal storage disorders, characterized by altered metabolism of heparan sulfate, cause autistic symptoms followed by dementia in children. Here, the authors show that embryonic dopaminergic neurodevelopmental defects due to altered function of heparan sulfate cause autistic behaviours in mice.

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results