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1. Genome-wide association study indicates novel associations of annexin A13 to secretory and GAS2L2 with mucous otitis media

Author

Argyro Bizaki-Vallaskangas, Joel Rämö, Eeva Sliz, Ilkka Kivekäs, Tytti Willberg, Elmo Saarentaus, Sanna Toppila-Salmi, Aarno Dietz, Teppo Haapaniemi, Vesa P. Hytönen, Sari Toivola, Aarno Palotie, Antti Mäkitie, and Johannes Kettunen

Subjects
Finngen, Otitis media, Genome-wide association, Annexin, GAS2L2, Eustachian tube, Medicine, Science
Abstract

Abstract To evaluate the genetics of chronic nonsuppurative otitis media (OM). We performed a genome-wide association study of 429,599 individuals included in the FinnGen study using three different case definitions: combined chronic nonsuppurative OM (7034 cases) (included serous and mucous chronic OM), mucous chronic OM (5953 cases), and secretory chronic OM (1689 cases). Individuals without otitis media were used as controls (417,745 controls). We used immunohistochemistry (IHC) of the murine middle ear to evaluate the expression of annexin A13. Four loci were significantly associated (p

Published
2024
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