1. Electronic control of H + current in a bioprotonic device with Gramicidin A and Alamethicin.
- Author
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Hemmatian Z, Keene S, Josberger E, Miyake T, Arboleda C, Soto-Rodríguez J, Baneyx F, and Rolandi M
- Subjects
- Biological Transport physiology, Electric Conductivity, Hydrogen-Ion Concentration, Lipid Bilayers chemistry, Membrane Potentials physiology, Permeability, Protons, Wearable Electronic Devices, Alamethicin chemistry, Cell Membrane metabolism, Gramicidin chemistry, Ion Channels chemistry, Ions metabolism
- Abstract
In biological systems, intercellular communication is mediated by membrane proteins and ion channels that regulate traffic of ions and small molecules across cell membranes. A bioelectronic device with ion channels that control ionic flow across a supported lipid bilayer (SLB) should therefore be ideal for interfacing with biological systems. Here, we demonstrate a biotic-abiotic bioprotonic device with Pd contacts that regulates proton (H
+ ) flow across an SLB incorporating the ion channels Gramicidin A (gA) and Alamethicin (ALM). We model the device characteristics using the Goldman-Hodgkin-Katz (GHK) solution to the Nernst-Planck equation for transport across the membrane. We derive the permeability for an SLB integrating gA and ALM and demonstrate pH control as a function of applied voltage and membrane permeability. This work opens the door to integrating more complex H+ channels at the Pd contact interface to produce responsive biotic-abiotic devices with increased functionality.- Published
- 2016
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