1. LDL receptor in alphavirus entry: structural analysis and implications for antiviral therapy.
- Author
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Wang N, Merits A, Veit M, Lello LS, Kong S, Jiao H, Chen J, Wang Y, Dobrikov G, Rey FA, and Su S
- Subjects
- Animals, Humans, Alphavirus Infections drug therapy, Alphavirus Infections virology, Protein Binding, Receptors, Virus metabolism, Receptors, Virus chemistry, Virion metabolism, Alphavirus drug effects, Alphavirus physiology, Alphavirus genetics, Antiviral Agents therapeutic use, Antiviral Agents pharmacology, Receptors, LDL metabolism, Receptors, LDL genetics, Virus Internalization drug effects
- Abstract
Various low-density lipoprotein receptors (LPRs) have been identified as entry factors for alphaviruses, and structures of the corresponding virion-receptor complexes have been determined. Here, we analyze the similarities and differences in the receptor binding modes of multiple alphaviruses to understand their ability to infect a wide range of hosts. We further discuss the challenges associated with the development of broad-spectrum treatment strategies against a diverse range of alphaviruses., (© 2024. The Author(s).)
- Published
- 2024
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