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Your search keyword '"Aerts, E."' showing total 5 results
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5 results on '"Aerts, E."'

1. Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients

Author

University of Helsinki, Department of Medicine, Mohty, M., Malard, F., Abecassis, M., Aerts, E., Alaskar, A. S., Aljurf, M., Arat, M., Bader, P., Baron, F., Bazarbachi, A., Blaise, D., Ciceri, F., Corbacioglu, S., Dalle, J-H, Dignan, F., Fukuda, T., Huynh, A., Masszi, T., Michallet, M., Nagler, A., NiChonghaile, M., Okamoto, S., Pagliuca, A., Peters, C., Petersen, F. B., Richardson, P. G., Ruutu, T., Savani, B. N., Wallhult, E., Yakoub-Agha, I., Duarte, R. F., Carreras, E., University of Helsinki, Department of Medicine, Mohty, M., Malard, F., Abecassis, M., Aerts, E., Alaskar, A. S., Aljurf, M., Arat, M., Bader, P., Baron, F., Bazarbachi, A., Blaise, D., Ciceri, F., Corbacioglu, S., Dalle, J-H, Dignan, F., Fukuda, T., Huynh, A., Masszi, T., Michallet, M., Nagler, A., NiChonghaile, M., Okamoto, S., Pagliuca, A., Peters, C., Petersen, F. B., Richardson, P. G., Ruutu, T., Savani, B. N., Wallhult, E., Yakoub-Agha, I., Duarte, R. F., and Carreras, E.

Abstract

Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (480%). Therefore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licensed for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for diagnosis, and a severity-grading system for SOS/VOD in adult patients, on behalf of the European Society for Blood and Marrow Transplantation.

Published
2016

2. Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives—a position statement from the European Society for Blood and Marrow Transplantation (EBMT)

Author

Fabio Ciceri, Tapani Ruutu, Mairead NiChonghaile, Anne Huynh, Enric Carreras, Ibrahim Yakoub-Agha, P. G. Richardson, As. Alaskar, C Peters, M. Abecassis, B.N. Savani, M. Mohty, Selim Corbacioglu, Tamás Masszi, J.-H. Dalle, Mutlu Arat, Takahiro Fukuda, Peter Bader, Frédéric Baron, M Aljurf, Ali Bazarbachi, Florent Malard, Arnon Nagler, Fb. Petersen, Elisabeth Wallhult, Didier Blaise, R. F. Duarte, T. Pagluica, Erik Aerts, Mauricette Michallet, Mohty, M, Malard, F, Abecassis, M, Aerts, E, Alaskar, A, Aljurf, M, Arat, M, Bader, P, Baron, F, Bazarbachi, A, Blaise, D, Ciceri, Fabio, Corbacioglu, S, Dalle, Jh, Duarte, Rf, Fukuda, T, Huynh, A, Masszi, T, Michallet, M, Nagler, A, Nichonghaile, M, Pagluica, T, Peters, C, Petersen, Fb, Richardson, Pg, Ruutu, T, Savani, Bn, Wallhult, E, Yakoub Agha, I, and Carreras, E.

Subjects
Position statement, Adult, medicine.medical_specialty, medicine.medical_treatment, genetic processes, Hematopoietic stem cell transplantation, Disease, Defibrotide, Postoperative Complications, Risk Factors, medicine, Humans, Vascular Diseases, Prospective cohort study, Intensive care medicine, Special Report, Transplantation, Marrow transplantation, business.industry, Hematopoietic Stem Cell Transplantation, Hematology, biochemical phenomena, metabolism, and nutrition, enzymes and coenzymes (carbohydrates), surgical procedures, operative, bacteria, Veno-Occlusive Disease, Complication, business, Biomarkers, medicine.drug
Abstract

Sinusoidal obstruction syndrome or veno-occlusive disease (SOS/VOD) is a potentially life-threatening complication of hematopoietic SCT (HSCT). This review aims to highlight, on behalf of the European Society for Blood and Marrow Transplantation, the current knowledge on SOS/VOD pathophysiology, risk factors, diagnosis and treatments. Our perspectives on SOS/VOD are (i) to accurately identify its risk factors; (ii) to define new criteria for its diagnosis; (iii) to search for SOS/VOD biomarkers and (iv) to propose prospective studies evaluating SOS/ VOD prevention and treatment in adults and children.

Published
2015

3. Prophylactic, preemptive, and curative treatment for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a position statement from an international expert group.

Author

Mohty M, Malard F, Abecasis M, Aerts E, Alaskar AS, Aljurf M, Arat M, Bader P, Baron F, Basak G, Bazarbachi A, Blaise D, Ciceri F, Corbacioglu S, Dalle JH, Dignan F, Fukuda T, Huynh A, Kuball J, Lachance S, Lazarus H, Masszi T, Michallet M, Nagler A, NiChonghaile M, Okamoto S, Pagliuca A, Peters C, Petersen FB, Richardson PG, Ruutu T, Saber W, Savani BN, Soiffer R, Styczynski J, Wallhult E, Yakoub-Agha I, Duarte RF, and Carreras E

Subjects
Adult, Humans, Polydeoxyribonucleotides, Hematopoietic Stem Cell Transplantation, Hepatic Veno-Occlusive Disease etiology, Hepatic Veno-Occlusive Disease prevention & control, Vascular Diseases
Published
2020
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4. Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation.

Author

Mohty M, Malard F, Abecassis M, Aerts E, Alaskar AS, Aljurf M, Arat M, Bader P, Baron F, Bazarbachi A, Blaise D, Ciceri F, Corbacioglu S, Dalle JH, Dignan F, Fukuda T, Huynh A, Masszi T, Michallet M, Nagler A, NiChonghaile M, Okamoto S, Pagliuca A, Peters C, Petersen FB, Richardson PG, Ruutu T, Savani BN, Wallhult E, Yakoub-Agha I, Duarte RF, and Carreras E

Subjects
Adult, Biomarkers, Early Diagnosis, Hepatic Veno-Occlusive Disease etiology, Hepatic Veno-Occlusive Disease therapy, Humans, Risk Factors, Sensitivity and Specificity, Severity of Illness Index, Hematopoietic Stem Cell Transplantation adverse effects, Hepatic Veno-Occlusive Disease diagnosis
Abstract

Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (>80%). Therefore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licensed for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for diagnosis, and a severity-grading system for SOS/VOD in adult patients, on behalf of the European Society for Blood and Marrow Transplantation.

Published
2016
Full Text
View/download PDF

5. Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives-a position statement from the European Society for Blood and Marrow Transplantation (EBMT).

Author

Mohty M, Malard F, Abecassis M, Aerts E, Alaskar AS, Aljurf M, Arat M, Bader P, Baron F, Bazarbachi A, Blaise D, Ciceri F, Corbacioglu S, Dalle JH, Duarte RF, Fukuda T, Huynh A, Masszi T, Michallet M, Nagler A, NiChonghaile M, Pagluica T, Peters C, Petersen FB, Richardson PG, Ruutu T, Savani BN, Wallhult E, Yakoub-Agha I, and Carreras E

Subjects
Adult, Biomarkers blood, Humans, Risk Factors, Hematopoietic Stem Cell Transplantation adverse effects, Postoperative Complications blood, Postoperative Complications diagnosis, Postoperative Complications physiopathology, Postoperative Complications therapy, Vascular Diseases blood, Vascular Diseases diagnosis, Vascular Diseases etiology, Vascular Diseases physiopathology, Vascular Diseases therapy
Abstract

Sinusoidal obstruction syndrome or veno-occlusive disease (SOS/VOD) is a potentially life-threatening complication of hematopoietic SCT (HSCT). This review aims to highlight, on behalf of the European Society for Blood and Marrow Transplantation, the current knowledge on SOS/VOD pathophysiology, risk factors, diagnosis and treatments. Our perspectives on SOS/VOD are (i) to accurately identify its risk factors; (ii) to define new criteria for its diagnosis; (iii) to search for SOS/VOD biomarkers and (iv) to propose prospective studies evaluating SOS/VOD prevention and treatment in adults and children.

Published
2015
Full Text
View/download PDF

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