1. Infectious diseases in the first year of life, perinatal characteristics and childhood acute leukaemia
- Author
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Emmanuel Plouvier, Patrick Boutard, Brigitte Pautard, Virginie Gandemer, Geneviève Margueritte, Xavier Rialland, Frédéric Millot, Denis Hémon, J L Lamagnére, J P Vannier, Y Perel, Martine Munzer, Christian Berthou, N Jourdan-Da Silva, Jacqueline Clavel, L. de Lumley, C Armari, Patrick Lutz, Francoise Mechinaud, Alain Robert, Kaniewski, Nadine, Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Pellegrin, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Hôpital mère et enfant, Hôpital Saint-Jacques, Hôpital Sud, hôpital Sud, Hôpital Civil, Hopital Civil, CHU Rouen, Normandie Université (NU), CHRU Clocheville, SFO Enseignement, SFO, Hôpital Côte de Nacre [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Pôle Enfants [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Hôpital de la Tronche, American Memorial Hospital, American Memory Hospital, Hôpital Jean Bernard, CHU Limoges, Hôpital Morvan, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre Robert Debré, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), CHU Amiens-Picardie, and Hôpital d'enfants
- Subjects
Male ,Cancer Research ,Pediatrics ,MESH: Asthma ,Epidemiology ,MESH: Leukemia, Myeloid ,MESH: Child Day Care Centers ,Infant, Newborn, Diseases ,0302 clinical medicine ,MESH: Leukemia, Lymphocytic, Acute ,Risk Factors ,Odds Ratio ,Medicine ,030212 general & internal medicine ,Medical History Taking ,education.field_of_study ,MESH: Infant, Newborn ,Age Factors ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,MESH: Infant ,MESH: Case-Control Studies ,3. Good health ,Birth order ,Breast Feeding ,Oncology ,Leukemia, Myeloid ,030220 oncology & carcinogenesis ,MESH: Breast Feeding ,leukaemia ,Acute Disease ,MESH: Acute Disease ,Regression Analysis ,Female ,France ,MESH: Infection ,medicine.medical_specialty ,Population ,MESH: Infant, Newborn, Diseases ,Infections ,03 medical and health sciences ,MESH: Birth Order ,Humans ,Medical history ,education ,perinatal ,childhood ,MESH: Age Factors ,MESH: Humans ,business.industry ,Case-control study ,Infant, Newborn ,Infant ,Odds ratio ,Child Day Care Centers ,MESH: Male ,Asthma ,MESH: France ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Case-Control Studies ,Etiology ,MESH: Me ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Birth Order ,business ,Breast feeding ,MESH: Female - Abstract
The objective of the present study was to investigate the role of early common infections and perinatal characteristics in the aetiology of childhood common leukaemia. A case-control study was conducted from 1995 to 1998 in France, and included 473 incident cases of acute leukaemia (AL) (408 acute lymphoblastic leukaemia (ALL), 65 acute myeloid leukaemia (AML) age-, sex- and region-matched with 567 population-based controls. Data on the medical history of the child and his/her environment were collected using self-administered questionnaires. Analyses were conducted using nonconditional logistic regression. A slight negative association with early infections was observed (OR=0.8; 95% CI (0.6-1.0)). The association was stronger for early gastrointestinal infections. Early day-care was found to be associated with a decreased risk of AL (OR=0.6; 95% CI (0.4-0.8) and OR=0.8; 95% CI (0.5-1.2) for day-care starting before age 3 months and between 3 and 6 months, respectively). No association with breast-feeding was observed, irrespective of its duration. A birth order of 4 or more was associated with a significantly increased risk of AL (OR=2.0; 95% CI (1.1-3.7) with ALL). A history of asthma was associated with a decreased risk of ALL (OR 0.5; 95% CI (0.3-0.90). Although the results regarding birth order and breast-feeding do not fit with Greaves' hypothesis, the study supports the hypothesis that early common infections may play a protective role in the aetiology of childhood leukaemia, although this effect was not more marked for common ALL.
- Published
- 2004
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