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Your search keyword '"Bruns, Anke H W"' showing total 4 results
Start Over Author "Bruns, Anke H W" Publisher nature publishing group
4 results on '"Bruns, Anke H W"'

1. Disseminated nontuberculous mycobacterial infections after allogeneic hematopoietic stem cell transplantation: a risk-based strategy for early diagnosis

Author

MS Hematologie, Cancer, MMB Medische Staf, Infection & Immunity, Pathologie Pathologen staf, MMB opleiding Arts microbioloog, CTI De Witte, Regenerative Medicine and Stem Cells, MS Interne Geneeskunde, CTI Kuball, Daenen, Laura G M, van der Bruggen, Jan-Tom, Leguit, Roos J, van der Wagen, Lotte E, van Rhenen, Anna, Wunderink, Herman F, de Witte, Moniek A, Bruns, Anke H W, Kuball, Jurgen, MS Hematologie, Cancer, MMB Medische Staf, Infection & Immunity, Pathologie Pathologen staf, MMB opleiding Arts microbioloog, CTI De Witte, Regenerative Medicine and Stem Cells, MS Interne Geneeskunde, CTI Kuball, Daenen, Laura G M, van der Bruggen, Jan-Tom, Leguit, Roos J, van der Wagen, Lotte E, van Rhenen, Anna, Wunderink, Herman F, de Witte, Moniek A, Bruns, Anke H W, and Kuball, Jurgen

Published
2023

2. Disseminated nontuberculous mycobacterial infections after allogeneic hematopoietic stem cell transplantation: a risk-based strategy for early diagnosis.

Author

Daenen LGM, van der Bruggen JT, Leguit RJ, van der Wagen LE, van Rhenen A, Wunderink HF, de Witte MA, Bruns AHW, and Kuball J

Subjects
Humans, Early Diagnosis, Hematopoietic Stem Cell Transplantation adverse effects, Mycobacterium Infections, Nontuberculous diagnosis, Mycobacterium Infections, Nontuberculous etiology
Published
2023
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4. Predictive factors for vaccine failure to guide vaccination in allogeneic hematopoietic stem cell transplant recipients.

Author

Janssen MJM, Bruns AHW, Verduyn Lunel FM, Raijmakers RAP, de Weijer RJ, Nanlohy NM, Smits GP, van Baarle D, and Kuball J

Subjects
Humans, Immunization Schedule, Pneumococcal Vaccines, Vaccination, Antibodies, Bacterial, Hematopoietic Stem Cell Transplantation
Abstract

Vaccination after hematopoietic stem cell transplantation (HSCT) is essential to protect high-risk patients against potentially lethal infections. Though multiple studies have evaluated vaccine specific responses, no comprehensive analysis of a complete vaccination schedule post-HSCT has been performed and little is known about predictors for vaccine failure. In this context, allogeneic HSCT (alloHSCT) patients were included and vaccinated starting one year post-transplantation. Antibody responses were measured by Multiplex Immuno Assay for pneumococcal (PCV13), meningococcal C, diphtheria, pertussis, tetanus and Haemophilus influenza type b one month after the last vaccination and correlated to clinical and immunological parameters. Vaccine failure was defined as antibody response above vaccine-specific cut-off values for less than four out of six vaccines. Ninety-six patients were included of which 27.1% was found to have vaccine failure. Only 40.6% of all patients responded adequately to all six vaccines. In multivariate analysis, viral reactivation post-HSCT (OR 6.53; P = 0.03), B-cells <135 per mm 3 (OR 7.24; P = 0.00) and NK-cells <170 per mm 3 (OR 11.06; P = 0.00) were identified as predictors for vaccine failure for vaccination at one year post-alloHSCT. Measurement of antibody responses and an individualized approach for revaccination guided by clinical status and immune reconstitution of B-cells and NK-cells may improve vaccine responses., (© 2021. The Author(s), under exclusive licence to Springer Nature Limited.)

Published
2021
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