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Your search keyword '"F. Savigny"' showing total 3 results
Start Over Author "F. Savigny" Publisher nature publishing group
3 results on '"F. Savigny"'

1. ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation

Author

Nicolas Riteau, François Rassendren, B. Villeret, Aurélie Gombault, Noëlline Guillou, F. Savigny, Bernhard Ryffel, Ludivine Baron, Isabelle Couillin, M. Le Bert, Immunologie et Neurogénétique Expérimentales et Moléculaires (INEM), and Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)

Subjects
Cancer Research, Inflammasomes, Interleukin-1beta, Uridine Triphosphate, danger signal, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, Connexins, chemistry.chemical_compound, Mice, 0302 clinical medicine, Adenosine Triphosphate, Cysteine Proteases, Cells, Cultured, 0303 health sciences, P2R, Purinergic receptor, Receptors, Purinergic, Inflammasome, Pannexin, Purinergic signalling, Silicon Dioxide, 3. Good health, Cell biology, Adenosine Diphosphate, Original Article, Signal transduction, medicine.drug, Signal Transduction, Immunology, Biology, NLR, 03 medical and health sciences, Cellular and Molecular Neuroscience, inflammasome, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Animals, Humans, 030304 developmental biology, Innate immune system, Macrophages, Cell Biology, Immunity, Innate, Uric Acid, ATP, Adenosine diphosphate, chemistry, Carrier Proteins, Adenosine triphosphate, 030217 neurology & neurosurgery, Aluminum
Abstract

International audience; Deposition of uric acid crystals in joints causes the acute and chronic inflammatory disease known as gout and prolonged airway exposure to silica crystals leads to the development of silicosis, an irreversible fibrotic pulmonary disease. Aluminum salt (Alum) crystals are frequently used as vaccine adjuvant. The mechanisms by which crystals activate innate immunity through the Nlrp3 inflammasome are not well understood. Here, we show that uric acid, silica and Alum crystals trigger the extracellular delivery of endogenous ATP, which just precedes the secretion of mature interleukin-1β (IL-1β) by macrophages, both events depending on purinergic receptors and connexin/pannexin channels. Interestingly, not only ATP but also ADP and UTP are involved in IL-1β production upon these Nlrp3 inflammasome activators through multiple purinergic receptor signaling. These findings support a pivotal role for nucleotides as danger signals and provide a new molecular mechanism to explain how chemically and structurally diverse stimuli can activate the Nlrp3 inflammasome.

Published
2012
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2. Hybrid VMAT-3DCRT as breast cancer treatment improvement tool.

Author

Voyant C, Pinpin M, Leschi D, Prapant S, Savigny F, and Acquaviva MA

Subjects
Humans, Female, Radiotherapy Planning, Computer-Assisted methods, Breast, Radiotherapy Dosage, Organs at Risk, Breast Neoplasms radiotherapy, Radiotherapy, Intensity-Modulated methods, Radiotherapy, Conformal methods
Abstract

Radiation therapy is an important tool in the treatment of breast cancer and can play a crucial role in improving patient outcomes. For breast cancer, if the technique has been for a long time the use of 3DCRT, clinicians have seen the management evolve greatly in recent years. Field-in-field and IMRT approaches and more recently dynamic arctherapy are increasingly available. All of these approaches are constantly trying to improve tumour coverage and to preserve organs at risk by minimising the doses delivered to them. If arctherapy allows a considerable reduction of high doses received by healthy tissues, no one can deny that it also leads to an increase of low doses in tissues that would not have received any with other techniques. We propose a hybrid approach combining the robustness of the 3DCRT approach and the high technicality and efficiency of arctherapy. Statistical tests (ANOVA, Wilcoxon, determination coefficient, ROC, etc.) allow us to draw conclusions about the possibility of using the hybrid approach in certain cases (right breast, BMI [Formula: see text], age [Formula: see text], target volume [Formula: see text] cc, etc.). Depending on the breast laterality and patients morphological characteristics, hybridization may prove to be a therapeutic tool of choice in the management of breast cancer in radiotherapy., (© 2024. The Author(s).)

Published
2024
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3. Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice.

Author

Nascimento M, Gombault A, Lacerda-Queiroz N, Panek C, Savigny F, Sbeity M, Bourinet M, Le Bert M, Riteau N, Ryffel B, Quesniaux VFJ, and Couillin I

Subjects
Animals, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Repetitive Sequences, Nucleic Acid, DNA metabolism, Membrane Proteins metabolism, Nucleotidyltransferases metabolism, Pneumonia metabolism, Pulmonary Emphysema metabolism, Receptor, Interferon alpha-beta metabolism, Tobacco Smoke Pollution adverse effects
Abstract

Cigarette smoke exposure is a leading cause of chronic obstructive pulmonary disease (COPD), a major health issue characterized by airway inflammation with fibrosis and emphysema. Here we demonstrate that acute exposure to cigarette smoke causes respiratory barrier damage with the release of self-dsDNA in mice. This triggers the DNA sensor cGAS (cyclic GMP-AMP synthase) and stimulator of interferon genes (STING), driving type I interferon (IFN I) dependent lung inflammation, which are attenuated in cGAS, STING or type I interferon receptor (IFNAR) deficient mice. Therefore, we demonstrate a critical role of self-dsDNA release and of the cGAS-STING-type I interferon pathway upon cigarette smoke-induced damage, which may lead to therapeutic targets in COPD.

Published
2019
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