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Your search keyword '"Gad, Hans-Henrik"' showing total 4 results
Start Over Author "Gad, Hans-Henrik" Publisher nature publishing group
4 results on '"Gad, Hans-Henrik"'

1. Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses

Author

Holm, Christian K, Rahbek, Stine H, Gad, Hans Henrik, Bak, Rasmus O, Jakobsen, Martin R, Jiang, Zhaozaho, Hansen, Anne Louise, Jensen, Simon K, Sun, Chenglong, Thomsen, Martin K, Laustsen, Anders, Nielsen, Camilla G, Severinsen, Kasper, Xiong, Yingluo, Burdette, Dara L, Hornung, Veit, Lebbink, Robert Jan, Duch, Mogens, Fitzgerald, Katherine A, Bahrami, Shervin, Mikkelsen, Jakob Giehm, Hartmann, Rune, Paludan, Søren R, Holm, Christian K, Rahbek, Stine H, Gad, Hans Henrik, Bak, Rasmus O, Jakobsen, Martin R, Jiang, Zhaozaho, Hansen, Anne Louise, Jensen, Simon K, Sun, Chenglong, Thomsen, Martin K, Laustsen, Anders, Nielsen, Camilla G, Severinsen, Kasper, Xiong, Yingluo, Burdette, Dara L, Hornung, Veit, Lebbink, Robert Jan, Duch, Mogens, Fitzgerald, Katherine A, Bahrami, Shervin, Mikkelsen, Jakob Giehm, Hartmann, Rune, and Paludan, Søren R

Published
2016

2. Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses

Author

MMB Research line 3a, Infection & Immunity, Holm, Christian K, Rahbek, Stine H, Gad, Hans Henrik, Bak, Rasmus O, Jakobsen, Martin R, Jiang, Zhaozaho, Hansen, Anne Louise, Jensen, Simon K, Sun, Chenglong, Thomsen, Martin K, Laustsen, Anders, Nielsen, Camilla G, Severinsen, Kasper, Xiong, Yingluo, Burdette, Dara L, Hornung, Veit, Lebbink, Robert Jan, Duch, Mogens, Fitzgerald, Katherine A, Bahrami, Shervin, Mikkelsen, Jakob Giehm, Hartmann, Rune, Paludan, Søren R, MMB Research line 3a, Infection & Immunity, Holm, Christian K, Rahbek, Stine H, Gad, Hans Henrik, Bak, Rasmus O, Jakobsen, Martin R, Jiang, Zhaozaho, Hansen, Anne Louise, Jensen, Simon K, Sun, Chenglong, Thomsen, Martin K, Laustsen, Anders, Nielsen, Camilla G, Severinsen, Kasper, Xiong, Yingluo, Burdette, Dara L, Hornung, Veit, Lebbink, Robert Jan, Duch, Mogens, Fitzgerald, Katherine A, Bahrami, Shervin, Mikkelsen, Jakob Giehm, Hartmann, Rune, and Paludan, Søren R

Published
2016

3. Establishment of well-differentiated camelid airway cultures to study Middle East respiratory syndrome coronavirus.

Author

Gultom M, Kratzel A, Portmann J, Stalder H, Chanfon Bätzner A, Gantenbein H, Gurtner C, Ebert N, Gad HH, Hartmann R, Posthaus H, Zanolari P, Pfaender S, Thiel V, and Dijkman R

Subjects
Animals, Camelus, Respiratory System, Camelids, New World, Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus
Abstract

In 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in Saudi Arabia and was mostly associated with severe respiratory illness in humans. Dromedary camels are the zoonotic reservoir for MERS-CoV. To investigate the biology of MERS-CoV in camelids, we developed a well-differentiated airway epithelial cell (AEC) culture model for Llama glama and Camelus bactrianus. Histological characterization revealed progressive epithelial cellular differentiation with well-resemblance to autologous ex vivo tissues. We demonstrate that MERS-CoV displays a divergent cell tropism and replication kinetics profile in both AEC models. Furthermore, we observed that in the camelid AEC models MERS-CoV replication can be inhibited by both type I and III interferons (IFNs). In conclusion, we successfully established camelid AEC cultures that recapitulate the in vivo airway epithelium and reflect MERS-CoV infection in vivo. In combination with human AEC cultures, this system allows detailed characterization of the molecular basis of MERS-CoV cross-species transmission in respiratory epithelium., (© 2022. The Author(s).)

Published
2022
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4. Two cGAS-like receptors induce antiviral immunity in Drosophila.

Author

Holleufer A, Winther KG, Gad HH, Ai X, Chen Y, Li L, Wei Z, Deng H, Liu J, Frederiksen NA, Simonsen B, Andersen LL, Kleigrewe K, Dalskov L, Pichlmair A, Cai H, Imler JL, and Hartmann R

Subjects
Amino Acid Sequence, Animals, Cell Line, Drosophila Proteins metabolism, Drosophila melanogaster metabolism, Drosophila melanogaster virology, Female, Humans, Immunity, Innate genetics, Immunity, Innate immunology, Ligands, Male, Membrane Proteins metabolism, Models, Molecular, NF-kappa B metabolism, Nucleotides, Cyclic metabolism, Nucleotidyltransferases classification, Nucleotidyltransferases deficiency, Nucleotidyltransferases metabolism, RNA, Double-Stranded analysis, RNA, Double-Stranded immunology, RNA, Double-Stranded metabolism, Receptors, Pattern Recognition classification, Receptors, Pattern Recognition deficiency, Receptors, Pattern Recognition immunology, Drosophila melanogaster immunology, Nucleotidyltransferases immunology, Receptors, Pattern Recognition metabolism, Viruses immunology
Abstract

In mammals, cyclic GMP-AMP (cGAMP) synthase (cGAS) produces the cyclic dinucleotide 2'3'-cGAMP in response to cytosolic DNA and this triggers an antiviral immune response. cGAS belongs to a large family of cGAS/DncV-like nucleotidyltransferases that is present in both prokaryotes 1 and eukaryotes 2-5 . In bacteria, these enzymes synthesize a range of cyclic oligonucleotides and have recently emerged as important regulators of phage infections 6-8 . Here we identify two cGAS-like receptors (cGLRs) in the insect Drosophila melanogaster. We show that cGLR1 and cGLR2 activate Sting- and NF-κB-dependent antiviral immunity in response to infection with RNA or DNA viruses. cGLR1 is activated by double-stranded RNA to produce the cyclic dinucleotide 3'2'-cGAMP, whereas cGLR2 produces a combination of 2'3'-cGAMP and 3'2'-cGAMP in response to an as-yet-unidentified stimulus. Our data establish cGAS as the founding member of a family of receptors that sense different types of nucleic acids and trigger immunity through the production of cyclic dinucleotides beyond 2'3'-cGAMP., (© 2021. The Author(s), under exclusive licence to Springer Nature Limited.)

Published
2021
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