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Background/Objectives: Homocysteine (Hcy) is a key intermediate in methionine metabolism. A high plasma concentration of Hcy is an independent risk factor for cardiovascular diseases among other determinants. In this study, we aimed to investigate the interactions between methylenetetrahydrofolate reductase enzyme gene (MTHFR) polymorphisms and lifestyle variables (smoking, alcohol intake and physical activity) on Hcy concentrations in a young Brazilian population. Subjects/Methods: The study population comprised 3803 individuals from the Pelotas Birth Cohort, aged 22-23 years. Allelic discrimination assays and chemiluminescence immunoassays were performed for genotyping and serum Hcy measurements, respectively. Linear regression models were used to explore the effect of gene-lifestyle interactions on Hcy concentrations. Results: Men carrying the MTHFR 677TT genotype, who were also smokers and drinkers ([succeeds/equal to]15 g of alcohol per day), had the highest concentration of Hcy (P-value for the interaction [less than] 0.001 for smoking and 0.002 for alcohol intake). In contrast, high folate concentrations attenuated the effects of the MTHFR C677T genotype on serum Hcy concentrations (P-value for interaction [less than] 0.001). Also, among males, blood folate concentration was the only lifestyle variable able to modify the influence of MTHFR A1298C genotypes on Hcy concentrations (P-value for the interaction [less than] 0.001). There was no strong evidence of an interaction between the MTHFR genotypes and the lifestyle variables in women. Conclusions: In summary, our study demonstrates a sex difference in Hcy concentrations among Brazilian young adults regarding MTHFR C677T-lifestyle interactions that are worsened under conditions of low blood folate. Identification of potentially modifiable factors related to an increase in homocysteine in young adults, especially in those who are genetically susceptible, is important to prevent negative health consequences in the future. European Journal of Clinical Nutrition (2017) 71, 259-266; doi: 10.1038/ejcn.2016.193; published online 19 October 2016, Author(s): I O Oliveira [1]; L P Silva [2]; M C Borges [3]; O M Cruz [2]; J W Tessmann [2]; J V S Motta [3]; F K Seixas [2]; [...]

Objective: To study the prevalence and current predictors of low body mass index (BMI) in a population undergoing a rapid nutritional transition. Design: Population-based cross-sectional study. Settings: Individuals living in the urban area of Pelotas, a medium-sized southern Brazilian city, were interviewed at home. Subjects: A multiple-stage sampling strategy was used. Out of 3372 eligible subjects, 3047 were interviewed. The study was restricted to adults ([greater than or equal to]20 y). Main outcome measure: Low BMI was defined as [less than] 18.5 kg/m[sup.2]. Results: The prevalence of low BMI was 2.7% (95% confidence interval: 2.1; 3.3), higher in women than men (3.8 vs 1.3%; P [less than] 0.001). In the whole sample (men and women combined), living without a partner and current smoking were positively associated with low BMI. Among women, low BMI presented a U-shaped relationship with age and was positively associated with educational level. The prevalence of low BMI in young women was 6.3%, and in highly educated young women was 8.9%. Conclusions: Consistently with previous Brazilian studies, a decline in the overall prevalence of low BMI is clear. However, differently from these studies, the predictors of low BMI in women are similar to those observed within developed countries (including low age and high education), possibly indicating an increase in eating disorders. European Journal of Clinical Nutrition (2005) 59, 1002-1006. doi: 10.1038/sj.ejcn.1602204; published online 22 June 2005 Keywords: body mass index, chronic energy deficiency, nutritional transition, nutritional status, underweight, Author(s): P C Hallal [1]; J C K Wells [2]; A D Bertoldi [1]; F K Gazalle [3]; M C Silva [1]; M R Domingues [1]; M L V Carret [...]

Despite the remarkable growth of the global market for robotics, robotic monitoring of habitats is still an understudied topic. This is true, among others, for the species-rich EU Annex I habitat "6210 - Semi-natural grasslands and scrubland facies on calcareous substrates". This habitat is typically surveyed by human operators. In this work, we present a dataset concerning relevés performed through the quadrupedal robot ANYmal C. The dataset contains information from three plots, which include the robot state, videos, and images acquired to assess the habitat conservation status. Additionally, a collection of videos and pictures about two typical and one early warning species of habitat 6210 is also presented. This database is publicly available in the provided Zenodo repository and will aid researchers in several fields. Robot state information can be used by engineers to validate their algorithms, while data gathered by the robot can be used to design new methodologies and new metrics to assess the habitat conservation status or train/test classifiers (e.g. neural networks) for plant classification., (© 2023. The Author(s).)

Background/objectives: The aim of this study was to investigate the association between stunting in the second year of life and metabolic syndrome components in early adulthood among subjects who have been prospectively followed-up since birth, in a city in Southern Brazil., Subjects/methods: In 1984, we attempted to follow-up the entire cohort; the subjects were examined and their mothers interviewed. Stunting was defined by a length-for-age Z-score 2 s.d. or more below the mean, in accordance with the World Health Organization reference. Between 2004 and 2005, we again tried to follow the entire cohort; during this period the subjects were evaluated for the following metabolic syndrome components: high-density lipoprotein (HDL) cholesterol, triglycerides, random blood glucose, waist circumference and systolic and diastolic blood pressure. Family income at the time of the baby's birth, asset index, mother's education, mother's smoking during pregnancy and duration of breastfeeding were considered possible confounders. Linear regression was used in the unadjusted and adjusted analyses., Results: Among men, stunting was inversely associated with triglycerides (β=-11.90, confidence interval (CI)=-22.33 to -1.48) and waist circumference (β=-4.29, CI=-5.62 to -2.97), whereas for women stunting was negatively related to HDL-cholesterol (β=-4.50, CI=-6.47 to -2.52), triglycerides (β=-9.61, CI=-17.66 to -1.56) and waist circumference (β=-1.14, CI=-4.22 to -1.02). However, after controlling for confounding variables, these associations vanished., Conclusions: The findings suggest that stunting in childhood is not associated with metabolic syndrome components in young adults.

Background/objectives: To identify the prevalence and factors associated with body dissatisfaction., Subjects/methods: Birth cohort study investigating 4100 subjects (2187 men and 1913 women) aged between 22 and 23 years who answered questionnaires, including the body satisfaction Stunkard Scale were included in the study; they were weighed and measured. Multinomial logistic regression was used in the crude and adjusted analyses., Results: The prevalence of body dissatisfaction was 64% (95% CI, 62.7-65.6); 42% (95% CI, 40.6-43.6) of the subjects reported feeling larger than the desired body size, and 22% (95% CI, 20.7-23.3) reported feeling smaller than desired. Underweight subjects, subjects with less schooling, poor and sedentary male subjects with low psychological well-being and female subjects who were already mothers were more likely to express body dissatisfaction, perceiving their body as smaller than the desirable body size. The prevalence of body dissatisfaction was also high among overweight subjects, subjects with a high socioeconomic status and married female subjects, who perceived their body size as too large. Minor psychiatric disorders were associated with body dissatisfaction in all subjects, regardless of perceiving themselves as larger or smaller than the desired body size. Most women perceived themselves as larger, but similar proportions of men perceived themselves as too small or too large., Conclusions: Body dissatisfaction was observed among men and women with normal weight, but it was more evident in the obese individuals. Regardless of the nutritional status, both men and women should be appropriately counseled because body size perception can lead to unhealthy behaviors in relation to diet and physical activity.

Background/objective: To investigate socioeconomic, gestational and early life exposures as potential determinants of total height, leg and trunk length., Subjects/methods: Male subjects from the 1982 Pelotas Birth Cohort Study were examined in 1986 at home, and in 2000 when registering at the local army base. The follow-up rate was 79%. Standing and sitting heights were measured on both occasions. Leg length was calculated as the difference between standing and sitting heights. Outcome measures were height, leg and trunk length at 4 and 18 years and growth in this period. Complete data were obtained for 2012 participants, representing 71% of all eligible male subjects., Results: Mean (s.d.) height, trunk length and leg length at 18 years were 173.4 (6.8), 96.0 (3.5) and 77.5 cm (4.5), respectively. The mean (s.d.) change in height from 1986 to 2000 was 75.4 cm (5.2) and for leg and trunk length 35.4 (3.9) and 40.0 cm (2.9), respectively. Of 11 independent variables analyzed, only maternal height and birthweight were associated with all three variables of growth. Gestational age showed no associations with growth or attained size., Conclusions: Early growth plays a pivotal role in determining attained height and its components. Both biological and socioeconomic variables strongly influence determinants of height, though socioeconomic factors appear to be more important in early growth. Leg and trunk length contribute almost equally to differences in overall height, regardless of the independent variable influencing the difference. Public health strategies designed to improve chronic disease profiles should focus on the early growth period.