1. The acute effects of inulin and resistant starch on postprandial serum short-chain fatty acids and second-meal glycemic response in lean and overweight humans
- Author
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Rahat-Rozenbloom, S, Fernandes, J, Cheng, J, Gloor, G B, and Wolever, T M S
- Subjects
Starch -- Physiological aspects -- Health aspects ,Obesity -- Risk factors -- Development and progression ,Inulin -- Physiological aspects -- Health aspects ,Fatty acids -- Health aspects ,Glucose metabolism -- Health aspects ,Food/cooking/nutrition ,Health - Abstract
Background/Objectives: Colonic fermentation of dietary fiber to short-chain fatty acids (SCFA) may protect against obesity and diabetes, but excess production of colonic SCFA has been implicated in the promotion of obesity. We aimed to compare the effects of two fermentable fibers on postprandial SCFA and second-meal glycemic response in healthy overweight or obese (OWO) vs lean (LN) participants. Subjects/Methods: Using a randomized crossover design, 13 OWO and 12 LN overnight fasted participants were studied for 6 h on three separate days after consuming 300 ml water containing 75 g glucose (GLU) as control or with 24 g inulin (IN) or 28 g resistant starch (RS). A standard lunch was served 4 h after the test drink. Results: Within the entire group, compared with control, IN significantly increased serum SCFA (P Conclusions: RS has favorable second-meal effects, likely related to changes in FFA rather than SCFA concentrations. However, a longer study may be needed to demonstrate an effect of RS on SCFA. We found no evidence that acute increases in SCFA after IN reduce glycemic responses in humans, and we were unable to detect a significant difference in SCFA responses between OWO vs LN subjects., Author(s): S Rahat-Rozenbloom [sup.1] , J Fernandes [sup.1] , J Cheng [sup.2] , G B Gloor [sup.3] , T M S Wolever [sup.1] [sup.4] Author Affiliations: (1) Department of Nutritional [...]
- Published
- 2017
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