1. Bendigoles A approximately C, new steroids from Gordonia australis Acta 2299.
- Author
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Schneider K, Graf E, Irran E, Nicholson G, Stainsby FM, Goodfellow M, Borden SA, Keller S, Süssmuth RD, and Fiedler HP
- Subjects
- Chromatography, High Pressure Liquid, Crystallography, X-Ray, Fermentation, Gordonia Bacterium classification, Gordonia Bacterium growth & development, Humans, Hydroxysteroids chemistry, Hydroxysteroids isolation & purification, Hydroxysteroids pharmacology, Magnetic Resonance Spectroscopy, Mass Spectrometry, Molecular Structure, Progesterone metabolism, Receptors, Androgen metabolism, Receptors, Estrogen drug effects, Receptors, Estrogen metabolism, Receptors, Mineralocorticoid drug effects, Receptors, Mineralocorticoid metabolism, Androgens biosynthesis, Androgens chemistry, Androgens isolation & purification, Androgens pharmacology, Gordonia Bacterium metabolism, Hydroxysteroids metabolism
- Abstract
Bendigoles A approximately C are the first secondary metabolites to be isolated from a member of the actinomycete genus Gordonia. They were detected in a culture filtrate extract of Gordonia australis Acta 2299 by HPLC-diode array analysis and characterized as new steroids by mass spectrometry and NMR experiments. Bendigole C show binding affinity to the human progesterone and A approximately C to androgen receptor but are inactive at mineralocorticoid and estrogen receptors. In in vitro transactivation studies bendigoles A and C showed moderate and weak androgenic activities.
- Published
- 2008
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