1. Exposure to acute normobaric hypoxia results in adaptions of both the macro- and microcirculatory system
- Author
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Mirna, M., Bimpong-Buta, N.-Y., Hoffmann, F., Abusamrah, T., Knost, T., Sander, O., Hew, Y. M., Lichtenauer, M., Muessig, J. M., Bruno, R. R., Kelm, M., Zange, J., Wilhelm, J., Limper, U., Jordan, J., Tank, J., and Jung, C.
- Subjects
Kardiovaskuläre Luft- und Raumfahrtmedizin ,Medical research ,Leitungsbereich ME ,Cardiology ,Pathogenesis ,Muskel- und Knochenstoffwechsel ,Hypoxia ,Institut für Luft- und Raumfahrtmedizin - Abstract
Although acute hypoxia is of utmost pathophysiologic relevance in health and disease, studies on its effects on both the macro- and microcirculation are scarce. Herein, we provide a comprehensive analysis of the effects of acute normobaric hypoxia on human macro- and microcirculation. 20 healthy participants were enrolled in this study. Hypoxia was induced in a normobaric hypoxia chamber by decreasing the partial pressure of oxygen in inhaled air stepwisely (pO₂; 21.25 kPa (0 k), 16.42 kPa (2 k), 12.63 kPa (4 k) and 9.64 kPa (6 k)). Macrocirculatory effects were assessed by cardiac output measurements, microcirculatory changes were investigated by sidestream dark-field imaging in the sublingual capillary bed and videocapillaroscopy at the nailfold. Exposure to hypoxia resulted in a decrease of systemic vascular resistance (p
- Published
- 2020