1. Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
- Author
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Arthur W. Musk, John P. Kemp, Ioanna Ntalla, Igor Rudan, Suzanne Miller, Anubha Mahajan, Samuli Ripatti, Nicholas J. Wareham, Alan F. Wright, Jennie Hui, Jing Hua Zhao, Jonathan Marten, Olli T. Raitakari, Henry Voelzke, John Beilby, John M. Starr, Robert A. Scott, Harry Campbell, Ma'en Obeidat, Deborah Jarvis, David C. Nickle, Markku Heliövaara, Nick Shrine, Lars Lind, David M. Evans, Richard Hubbard, John Henderson, Ozren Polasek, Panos Deloukas, James F. Wilson, María Soler Artigas, Ian P. Hall, Jennifer E. Huffman, Juan R. González, Joachim Heinrich, Mika Kähönen, Tim D. Spector, Neil C. Thomson, Christopher J Hammond, Marjo-Riitta Järvelin, Erik Ingelsson, Stefan Enroth, Ida Surakka, Andrew P. Morris, Ivana Kolcic, Louise V. Wain, Sarah H. Wild, Lynne J. Hocking, Wendy L. McArdle, Rajesh Rawal, Nina Hutri-Kähönen, Tatijana Zemunik, Åsa Johansson, Terho Lehtimäki, Christian Gieger, Veronique Vitart, Erik Melén, Sarah E. Harris, Medea Imboden, Holly Trochet, Momoko Horikoshi, Don D. Sin, Ian J. Deary, Pau Navarro, Alexessander Couto Alves, Ashok Kumar, Abdul Kader Kheirallah, Caroline Hayward, Stefan Karrasch, Alan James, Alexander Teumer, Ulf Gyllensten, Victoria E. Jackson, Eleftheria Zeggini, Ian D. Pavord, Holger Schulz, Anna-Liisa Hartikainen, Ana Viñuela, Anna Hansell, Nicole Probst-Hensch, Leo-Pekka Lyytikäinen, Pirro G. Hysi, Ian Sayers, Jonathan Marchini, Claudia Flexeder, David P. Strachan, Martin D. Tobin, Raquel Granell, Beate Stubbe, Corry-Anke Brandsma, Sven Glaeser, Janina S. Ried, Eva Albrecht, Yohan Bossé, Peter K. Joshi, Lorna M. Lopez, Sandosh Padmanabhan, Harald Grallert, Medical Research Council (MRC), Groningen Research Institute for Asthma and COPD (GRIAC), Institute for Molecular Medicine Finland, Clinicum, Department of Public Health, Biostatistics Helsinki, and Complex Disease Genetics
- Subjects
Lung Diseases ,Male ,Vital capacity ,UK BiLEVE ,General Physics and Astronomy ,Genome-wide association study ,0302 clinical medicine ,Missing heritability problem ,MISSING HERITABILITY ,Forced Expiratory Volume ,Genotype ,SEQUENCE VARIANTS ,WIDE ASSOCIATION ,SUSCEPTIBILITY LOCUS ,Lung ,GENE-EXPRESSION ,Genetics ,Aged, 80 and over ,0303 health sciences ,ARCHITECTURE ,Multidisciplinary ,Middle Aged ,Aparell respiratori ,3. Good health ,ddc ,Multidisciplinary Sciences ,Science & Technology - Other Topics ,Female ,Adult ,European Continental Ancestry Group ,Biology ,OBSTRUCTIVE PULMONARY-DISEASE ,Polymorphism, Single Nucleotide ,White People ,Article ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,FEV1/FVC ratio ,Young Adult ,MD Multidisciplinary ,Humans ,SMOKING-BEHAVIOR ,1000 Genomes Project ,Genetik ,METAANALYSIS ,030304 developmental biology ,Aged ,Science & Technology ,spirometry ,lung function ,genetics ,ta1184 ,General Chemistry ,ta3121 ,Heritability ,030228 respiratory system ,3121 General medicine, internal medicine and other clinical medicine ,Pulmons ,FORCED VITAL CAPACITY ,Imputation (genetics) ,Genètica ,Genome-Wide Association Study - Abstract
Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P, Genetic and environmental factors impact on lung function, important in the diagnosis of pulmonary diseases. Here the authors use imputation of genotypes to the 1000 Genomes Project reference panel to identify novel, low frequency variants associated with lung function.
- Published
- 2015