Search

Your search keyword '"Koot, Yvonne E M"' showing total 3 results
Start Over Author "Koot, Yvonne E M" Publisher nature publishing group
3 results on '"Koot, Yvonne E M"'

1. An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF

Author

Koot, Yvonne E M, Van Hooff, Sander R., Boomsma, Carolien M., Van Leenen, Dik, Koerkamp, Marian J A Groot, Goddijn, Mariëtte, Eijkemans, Marinus J C, Fauser, Bart C J M, Holstege, Frank C P, Macklon, Nick S., Koot, Yvonne E M, Van Hooff, Sander R., Boomsma, Carolien M., Van Leenen, Dik, Koerkamp, Marian J A Groot, Goddijn, Mariëtte, Eijkemans, Marinus J C, Fauser, Bart C J M, Holstege, Frank C P, and Macklon, Nick S.

Published
2016

2. An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF

Author

Arts-assistenten DV&B, CMM Sectie Molecular Cancer Research, Groep Holstege, Cancer, CMM Groep Cuppen, Biostatistiek Onderzoek, JC onderzoeksprogramma Infectieziekten, Circulatory Health, JC onderzoeksprogramma Methodologie, MS VPG/Gynaecologie, Brain, Child Health, Koot, Yvonne E M, Van Hooff, Sander R., Boomsma, Carolien M., Van Leenen, Dik, Koerkamp, Marian J A Groot, Goddijn, Mariëtte, Eijkemans, Marinus J C, Fauser, Bart C J M, Holstege, Frank C P, Macklon, Nick S., Arts-assistenten DV&B, CMM Sectie Molecular Cancer Research, Groep Holstege, Cancer, CMM Groep Cuppen, Biostatistiek Onderzoek, JC onderzoeksprogramma Infectieziekten, Circulatory Health, JC onderzoeksprogramma Methodologie, MS VPG/Gynaecologie, Brain, Child Health, Koot, Yvonne E M, Van Hooff, Sander R., Boomsma, Carolien M., Van Leenen, Dik, Koerkamp, Marian J A Groot, Goddijn, Mariëtte, Eijkemans, Marinus J C, Fauser, Bart C J M, Holstege, Frank C P, and Macklon, Nick S.

Published
2016

3. An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF.

Author

Koot YE, van Hooff SR, Boomsma CM, van Leenen D, Groot Koerkamp MJ, Goddijn M, Eijkemans MJ, Fauser BC, Holstege FC, and Macklon NS

Subjects
Adult, Biopsy, Endometrium pathology, Female, Gene Expression Regulation, Humans, Pregnancy, Recurrence, Reproducibility of Results, Embryo Implantation genetics, Endometrium metabolism, Fertilization in Vitro, Gene Expression Profiling, Infertility, Female genetics
Abstract

The primary limiting factor for effective IVF treatment is successful embryo implantation. Recurrent implantation failure (RIF) is a condition whereby couples fail to achieve pregnancy despite consecutive embryo transfers. Here we describe the collection of gene expression profiles from mid-luteal phase endometrial biopsies (n = 115) from women experiencing RIF and healthy controls. Using a signature discovery set (n = 81) we identify a signature containing 303 genes predictive of RIF. Independent validation in 34 samples shows that the gene signature predicts RIF with 100% positive predictive value (PPV). The strength of the RIF associated expression signature also stratifies RIF patients into distinct groups with different subsequent implantation success rates. Exploration of the expression changes suggests that RIF is primarily associated with reduced cellular proliferation. The gene signature will be of value in counselling and guiding further treatment of women who fail to conceive upon IVF and suggests new avenues for developing intervention.

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results