1. Quantitative background parenchymal enhancement to predict recurrence after neoadjuvant chemotherapy for breast cancer.
- Author
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Moliere S, Oddou I, Noblet V, Veillon F, and Mathelin C
- Subjects
- Breast diagnostic imaging, Breast pathology, Breast Neoplasms diagnostic imaging, Disease-Free Survival, Female, Follow-Up Studies, Humans, Middle Aged, Multivariate Analysis, Neoplasm Recurrence, Local diagnostic imaging, Proportional Hazards Models, Breast Neoplasms pathology, Breast Neoplasms therapy, Magnetic Resonance Imaging, Neoadjuvant Therapy, Neoplasm Recurrence, Local pathology
- Abstract
Breast background parenchymal enhancement (BPE) is an increasingly studied MRI parameter that reflects the microvasculature of normal breast tissue, which has been shown to change during neoadjuvant chemotherapy (NAC) for breast cancer. We aimed at evaluating the BPE in patients undergoing NAC and its prognostic value to predict recurrence. MRI BPE was visually and quantitatively evaluated before and after NAC in a retrospective cohort of 102 women with unilateral biopsy-proven invasive breast cancer. Pre-therapeutic BPE was not predictive of pathological response or recurrence. Quantitative post-therapeutic BPE was significantly decreased compared to pre-therapeutic value. Post-therapeutic quantitative BPE significantly predicted recurrence (HR = 6.38 (0.71, 12.06), p < 0.05).
- Published
- 2019
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