1. MIC-1/GDF15 in Barrett's oesophagus and oesophageal adenocarcinoma
- Author
-
M L Thomas, David Brown, Natalia K. Botelho, Samuel N. Breit, Dan Falkenback, Reginald V. Lord, David C. Whiteman, Ka Ki Michelle Lee-Ng, Oliver M. Fisher, Yuri V. Bobryshev, Sarah J. Lord, and A. J. M. Levert-Mignon
- Subjects
Male ,Cancer Research ,medicine.medical_specialty ,Pathology ,Growth Differentiation Factor 15 ,Esophageal Neoplasms ,Oesophageal adenocarcinoma ,Adenocarcinoma ,intestinal metaplasia ,Gastroenterology ,03 medical and health sciences ,Barrett Esophagus ,0302 clinical medicine ,Internal medicine ,Medicine ,Macrophage Inhibitory Cytokine 1 ,Humans ,prognostic biomarker ,Molecular Diagnostics ,030304 developmental biology ,Aged ,Retrospective Studies ,0303 health sciences ,business.industry ,Case-control study ,Cancer ,Plasma levels ,Middle Aged ,medicine.disease ,Prognosis ,digestive system diseases ,3. Good health ,Barrett's oesophagus ,MIC-1 ,GDF15 ,Oncology ,030220 oncology & carcinogenesis ,Case-Control Studies ,Cancer and Oncology ,oesophageal adenocarcinoma ,Female ,progression ,business - Abstract
Background: Biomarkers are needed to improve current diagnosis and surveillance strategies for patients with Barrett's oesophagus (BO) and oesophageal adenocarcinoma (OAC). Macrophage inhibitory cytokine 1/growth differentiation factor 15 (MIC-1/GDF15) tissue and plasma levels have been shown to predict disease progression in other cancer types and was therefore evaluated in BO/OAC. Methods: One hundred thirty-eight patients were studied: 45 normal oesophagus (NE), 37 BO, 16 BO with low-grade dysplasia (LGD) and 40 OAC. Results: Median tissue expression of MIC-1/GDF15 mRNA was ⩾25-fold higher in BO and LGD compared to NE (P720 discriminated between the presence of either OAC or LGD vs NE with 94% sensitivity and 71% specificity (ROC AUC 0.86, 95% CI 0.73–0.96; P
- Published
- 2015