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Author(s): John Wilding [sup.1] [sup.2] Author Affiliations: (1) Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK (2) Clinical Sciences Centre, [...], A metabolic study comparing people who lost weight through dieting or through bariatric surgery shows that the effects on diabetes are due to weight loss.

Introduction Weight loss has been established as a fundamental approach in the prevention and treatment of diabetes mellitus; however, the underling mechanisms of increased insulin sensitivity and improved glycemic control [...], Intramyocellular diglycerides have been implicated in the development of insulin resistance. We aimed to evaluate the effect of weight loss, a well-known means for the improvement of insulin resistance, on intramyocellular diglycerides and triglycerides in type II diabetes. Participants were five obese women with type II diabetes (body mass index 37.5 ± 1.9 kg/[m.sup.2]), who participated in a weight loss program. The aim of the program was a reduction in body weight by 10%. Muscle biopsies were obtained before and after weight loss. The intervention induced a marked reduction in intramyocellular triglycerides by 77.7 ± 13.1%, whereas no significant differences were observed for diglycerides before and after weight loss. Our results indicate that weight loss due to negative energy balance depletes intramyocellular lipid storage without affecting intermediate molecules of lipid metabolism, such as intramyocellular diglycerides. European journal of Clinical Nutrition (2010) 64, 328-330; doi: 10.1038/ejcn.2009.157; published online 20 January 2010 Keywords: diglycerides; insulin resistance; intramyocellular lipids; obesity; skeletal muscle; triglycerides

Bariatric surgery is currently the moxst effective treatment option for obesity, resulting in substantial and durable weight loss with reduction in mortality and obesity-related comorbidites (1). Obesity is the primary [...]

Losing weight can pose a challenge, but how to avoid putting those pounds back on can be a real struggle. A major health problem for obese people is that diseases [...]