1. Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin
- Author
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Yukihiko Sugimoto, Judilyn Fuentes, Akihiko Kitoh, Hideo Yagita, Tetsuya Honda, Gyohei Egawa, Sachiko Ono, Atsushi Otsuka, Yohei Natsuaki, Yoichiro Iwakura, Sho Hanakawa, Lai Guan Ng, Emma Guttman-Yassky, Kenji Kabashima, Ken Ishii, Hiroko Tsutsui, Yoshiki Miyachi, Takashi Hashimoto, Satoshi Nakamizo, Soken Tsuchiya, Takaharu Okada, Nobuhiro Kusuba, Masato Kubo, and Saeko Nakajima
- Subjects
CD4-Positive T-Lymphocytes ,Chemokine ,Neutrophils ,Immunology ,Chemokine CXCL2 ,CD8-Positive T-Lymphocytes ,Dermatitis, Contact ,Lymphocyte Activation ,Receptors, Interleukin-8B ,Mice ,Antigen ,Interleukin-1alpha ,Immunology and Allergy ,Cytotoxic T cell ,Animals ,CXC chemokine receptors ,IL-2 receptor ,Antigen-presenting cell ,Cell Proliferation ,Skin ,Mice, Knockout ,biology ,integumentary system ,Macrophages ,Receptors, Interleukin-1 ,Dendritic Cells ,Lymphocyte Function-Associated Antigen-1 ,Cell biology ,CD11c Antigen ,Mice, Inbred C57BL ,CXCL2 ,Models, Animal ,Interleukin 12 ,biology.protein ,Female ,Immunologic Memory - Abstract
It remains largely unclear how antigen-presenting cells (APCs) encounter effector or memory T cells efficiently in the periphery. Here we used a mouse contact hypersensitivity (CHS) model to show that upon epicutaneous antigen challenge, dendritic cells (DCs) formed clusters with effector T cells in dermal perivascular areas to promote in situ proliferation and activation of skin T cells in a manner dependent on antigen and the integrin LFA-1. We found that DCs accumulated in perivascular areas and that DC clustering was abrogated by depletion of macrophages. Treatment with interleukin 1α (IL-1α) induced production of the chemokine CXCL2 by dermal macrophages, and DC clustering was suppressed by blockade of either the receptor for IL-1 (IL-1R) or the receptor for CXCL2 (CXCR2). Our findings suggest that the dermal leukocyte cluster is an essential structure for elicitating acquired cutaneous immunity., かぶれの発症における血管周囲の免疫細胞の集積の重要性の解明. 京都大学プレスリリース. 2014-09-24.
- Published
- 2014