1. Sex-specific associations of body composition measures with cardiac function and structure after 8 years of follow-up.
- Author
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Remmelzwaal S, Beulens JWJ, Elders PJM, Stehouwer CDA, Handoko ML, Appelman Y, van Empel V, Heymans SRB, and van Ballegooijen AJ
- Subjects
- Aged, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Adiposity, Hypertrophy, Left Ventricular pathology, Hypertrophy, Left Ventricular physiopathology, Obesity pathology, Obesity physiopathology, Sex Characteristics, Stroke Volume, Ventricular Dysfunction, Left pathology, Ventricular Dysfunction, Left physiopathology
- Abstract
We investigated the prospective associations of body composition with cardiac structure and function and explored effect modification by sex and whether inflammation was a mediator in these associations. Total body (BF), trunk (TF) and leg fat (LF), and total lean mass (LM) were measured at baseline by a whole body DXA scan. Inflammatory biomarkers and echocardiographic measures were determined both at baseline and follow-up in the Hoorn Study (n = 321). We performed linear regression analyses with body composition measures as determinant and left ventricular ejection fraction (LVEF), left ventricular mass index (LVMI) or left atrial volume index (LAVI) at follow-up as outcome. Additionally, we performed mediation analysis using inflammation at follow-up as mediator. The study population was 67.7 ± 5.2 years and 50% were female. After adjustment, BF, TF and LF, and LM were associated with LVMI with regression coefficients of 2.9 (0.8; 5.1)g/m
2.7 , 2.3 (0.6; 4.0)g/m2.7 , 2.0 (0.04; 4.0)g/m2.7 and - 2.9 (- 5.1; - 0.7)g/m2.7 . Body composition measures were not associated with LVEF or LAVI. These associations were not modified by sex or mediated by inflammation. Body composition could play a role in the pathophysiology of LV hypertrophy. Future research should focus on sex differences in regional adiposity in relation with diastolic dysfunction., (© 2021. The Author(s).)- Published
- 2021
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