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Your search keyword '"Evelyn B. Parr"' showing total 2 results
Start Over Author "Evelyn B. Parr" Publisher nature publishing group uk
2 results on '"Evelyn B. Parr"'

1. Author Correction: Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression

Author

Juleen R. Zierath, Leonidas S. Lundell, Paolo Sassone-Corsi, Shogo Sato, Lars R. Ingerslev, John A. Hawley, Brooke L. Devlin, Romain Barrès, Evelyn B. Parr, and Ali Altıntaş

Subjects
Adult, Male, Science, Metabolite, Metabolic disorders, General Physics and Astronomy, Gene Expression, Biology, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, Endocrinology, Circadian Clocks, Time restricted feeding, Humans, Amino Acids, lcsh:Science, Author Correction, Muscle, Skeletal, chemistry.chemical_classification, Multidisciplinary, Cross-Over Studies, General Chemistry, Fasting, Overweight, Lipid Metabolism, Lipids, Amino acid, Circadian Rhythm, CLOCK, chemistry, Biochemistry, lcsh:Q
Abstract

Time-restricted feeding (TRF) improves metabolism independent of dietary macronutrient composition or energy restriction. To elucidate mechanisms underpinning the effects of short-term TRF, we investigated skeletal muscle and serum metabolic and transcriptomic profiles from 11 men with overweight/obesity after TRF (8 h day

Published
2020

2. Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression

Author

Brooke L. Devlin, Leonidas S. Lundell, Paolo Sassone-Corsi, Romain Barrès, Shogo Sato, Ali Altıntaş, Juleen R. Zierath, Lars R. Ingerslev, Evelyn B. Parr, John A. Hawley, University of Copenhagen = Københavns Universitet (UCPH), Australian Catholic University (ACU), Department of Biological Chemistry [Irvine, CA, États-Unis], Center for Epigenetics and Metabolism [Irvine, CA, États-Unis], Institut National de la Santé et de la Recherche Médicale (INSERM)-University of California [Irvine] (UC Irvine), University of California (UC)-University of California (UC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-University of California [Irvine] (UC Irvine), University of California (UC)-University of California (UC), Karolinska Institutet [Stockholm], This research was supported by a Novo Nordisk Foundation Challenge Grant (NNF14OC0011493) to P.S-C., J.R.Z. and J.A.H., a Novo Nordisk Foundation Basic Metabolic Research Center Grant (NNF18CC003490) to J.R.Z., a Swedish Research Council, Distinguished Professor Award (2015-00165) to J.R.Z. and an ACURF grant (ACURF 2016000353) to J.A.H. Metabolon Inc. generated the metabolic analysis, and L.S.L., L.R.I, and A.A. performed the data analysis., Bodescot, Myriam, University of Copenhagen = Københavns Universitet (KU), Institut National de la Santé et de la Recherche Médicale (INSERM)-University of California [Irvine] (UCI), University of California-University of California-Institut National de la Santé et de la Recherche Médicale (INSERM)-University of California [Irvine] (UCI), and University of California-University of California

Subjects
0301 basic medicine, medicine.medical_specialty, Science, Metabolite, Metabolic disorders, General Physics and Astronomy, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Internal medicine, Gene expression, medicine, Amino acid transporter, lcsh:Science, chemistry.chemical_classification, [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Multidisciplinary, Chemistry, Skeletal muscle, Lipid metabolism, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, General Chemistry, Metabolism, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Amino acid, CLOCK, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, 030104 developmental biology, medicine.anatomical_structure, lcsh:Q, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, 030217 neurology & neurosurgery
Abstract

Time-restricted feeding (TRF) improves metabolism independent of dietary macronutrient composition or energy restriction. To elucidate mechanisms underpinning the effects of short-term TRF, we investigated skeletal muscle and serum metabolic and transcriptomic profiles from 11 men with overweight/obesity after TRF (8 h day−1) and extended feeding (EXF, 15 h day−1) in a randomised cross-over design (trial registration: ACTRN12617000165381). Here we show that muscle core clock gene expression was similar after both interventions. TRF increases the amplitude of oscillating muscle transcripts, but not muscle or serum metabolites. In muscle, TRF induces rhythmicity of several amino acid transporter genes and metabolites. In serum, lipids are the largest class of periodic metabolites, while the majority of phase-shifted metabolites are amino acid related. In conclusion, short-term TRF in overweight men affects the rhythmicity of serum and muscle metabolites and regulates the rhythmicity of genes controlling amino acid transport, without perturbing core clock gene expression., Time restricted feeding has several health benefits. Here the authors perform a randomised cross-over study with 11 men with overweight/obesity to investigate how time restricted feeding affects skeletal muscle and serum, and report that it does not affect the core circadian machinery, but modifies periodicity in amino acid related metabolites and transporters.

Published
2020
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