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Your search keyword '"Maaskola, Jonas"' showing total 6 results
Start Over Author "Maaskola, Jonas" Publisher nature publishing group uk
6 results on '"Maaskola, Jonas"'

1. Spatially resolved clonal copy number alterations in benign and malignant tissue

Author

Erickson, Andrew, He, Mengxiao, Berglund, Emelie, Marklund, Maja, Mirzazadeh, Reza, Schultz, Niklas, Kvastad, Linda, Andersson, Alma, Bergenstråhle, Ludvig, Bergenstråhle, Joseph, Larsson, Ludvig, Alonso Galicia, Leire, Shamikh, Alia, Basmaci, Elisa, Díaz De Ståhl, Teresita, Rajakumar, Timothy, Doultsinos, Dimitrios, Thrane, Kim, Ji, Andrew L., Khavari, Paul A., Tarish, Firaz, Tanoglidi, Anna, Maaskola, Jonas, Colling, Richard, Mirtti, Tuomas, Hamdy, Freddie C., Woodcock, Dan J., Helleday, Thomas, Mills, Ian G., Lamb, Alastair D., and Lundeberg, Joakim

Published
2022
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6. Spatial detection of fetal marker genes expressed at low level in adult human heart tissue

Author

Asp, Michaela, Salmén, Fredrik, Ståhl, Patrik L., Vickovic, Sanja, Felldin, Ulrika, Löfling, Marie, Fernandez Navarro, José, Maaskola, Jonas, Eriksson, Maria J., Persson, Bengt, Corbascio, Matthias, Persson, Hans, Linde, Cecilia, and Lundeberg, Joakim

Subjects
Adult, Male, Medicinska och farmaceutiska grundvetenskaper, Myocardium, lcsh:R, lcsh:Medicine, Gene Expression Regulation, Developmental, Basic Medicine, Middle Aged, Article, Fetus, Humans, lcsh:Q, lcsh:Science, Biomarkers, Aged
Abstract

Heart failure is a major health problem linked to poor quality of life and high mortality rates. Hence, novel biomarkers, such as fetal marker genes with low expression levels, could potentially differentiate disease states in order to improve therapy. In many studies on heart failure, cardiac biopsies have been analyzed as uniform pieces of tissue with bulk techniques, but this homogenization approach can mask medically relevant phenotypes occurring only in isolated parts of the tissue. This study examines such spatial variations within and between regions of cardiac biopsies. In contrast to standard RNA sequencing, this approach provides a spatially resolved transcriptome- and tissue-wide perspective of the adult human heart, and enables detection of fetal marker genes expressed by minor subpopulations of cells within the tissue. Analysis of patients with heart failure, with preserved ejection fraction, demonstrated spatially divergent expression of fetal genes in cardiac biopsies.

Published
2017

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