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2 results on '"Rovetto C"'

1. Epidemiological and molecular characterization of HBV and HCV infections in HIV-1-infected inmate population in Italy: a 2017–2019 multicenter cross-sectional study

Author

Maggiorella, Maria Teresa, Sernicola, L., Picconi, O., Pizzi, E., Belli, R., Fulgenzi, D., Rovetto, C., Bruni, R., Costantino, A., Taffon, S., Chionne, P., Madonna, E., Pisani, G., Borsetti, A., Falvino, C., Ranieri, R., Baccalini, R., Pansera, A., Castelvedere, F., Babudieri, S., Madeddu, G., Starnini, G., Dell’Isola, S., Cervellini, P., Ciccaglione, A. R., Ensoli, B., and Buttò, S.

Published
2023
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2. High HIV-1 diversity in immigrants resident in Italy (2008–2017)

Author

Maggiorella M. T., Sanarico N., Brindicci G., Monno L., Santoro C. R., Coppola N., Cuomo N., Azzurri A., Cesario F., Luciani F., El-Hamad I., D'Ettorre G., Turriziani O., Mazzuti L., Poggi A., Vichi F., Mariabelli E., Surace L., Berardelli G., Picconi O., Cenci A., Sernicola L., Rovetto C., Fulgenzi D., Belli R., Salvi E., Zeo P. D., Borsetti A., Ridolfi B., Losappio R., Zoboli F., Schietroma I., Cella E., Angeletti S., Ciccozzi M., D'Amato S., Ensoli B., Butto S., Angarano G., Babudieri S., Scheri G. C., Lichtner M., Martini S., Mazzella A., Romano N., Pansera A., Pontali E., Raddi A., Starnini G., Dell'Isola S., Maggiorella, M. T., Sanarico, N., Brindicci, G., Monno, L., Santoro, C. R., Coppola, N., Cuomo, N., Azzurri, A., Cesario, F., Luciani, F., El-Hamad, I., D'Ettorre, G., Turriziani, O., Mazzuti, L., Poggi, A., Vichi, F., Mariabelli, E., Surace, L., Berardelli, G., Picconi, O., Cenci, A., Sernicola, L., Rovetto, C., Fulgenzi, D., Belli, R., Salvi, E., Zeo, P. D., Borsetti, A., Ridolfi, B., Losappio, R., Zoboli, F., Schietroma, I., Cella, E., Angeletti, S., Ciccozzi, M., D'Amato, S., Ensoli, B., Butto, S., Angarano, G., Babudieri, S., Scheri, G. C., Lichtner, M., Martini, S., Mazzella, A., Romano, N., Pansera, A., Pontali, E., Raddi, A., Starnini, G., and Dell'Isola, S.

Subjects
0301 basic medicine, Male, Latin Americans, Immigration, Human immunodeficiency virus (HIV), lcsh:Medicine, HIV Infections, Drug resistance, medicine.disease_cause, Antiretroviral Therapy, Highly Active, Cluster Analysis, HIV Infection, lcsh:Science, Phylogeny, media_common, Recombination, Genetic, Multidisciplinary, Geography, virus diseases, High HIV-1 diversity in immigrants, Middle Aged, Italy, Medicine, Infectious diseases, Female, Human, Adult, Tuberculosis, media_common.quotation_subject, Science, 030106 microbiology, Emigrants and Immigrants, Article, 03 medical and health sciences, Population screening, Drug Resistance, Viral, medicine, Humans, Hepatitis, Cluster Analysi, lcsh:R, Genetic Variation, Emigrants and Immigrant, medicine.disease, Antiretroviral therapy, 030104 developmental biology, Mutation, HIV-1, lcsh:Q, Demography, Diversity (politics)
Abstract

The proportion of new diagnoses of HIV infection in immigrants residing in Italy raised from 11% in 1992 to 29.7% in 2018. To investigate the HIV clades circulating in this community a retrospective study was performed in 557 HIV-infected immigrants living in 12 Italian cities. Immigrants originated from East-Europe and Central-Asia (11.7%), North Africa and Middle East (7.3%), South and South-East Asia (7.2%), Latin America and the Caribbean (14.4%), and sub-Saharan Africa (59.4%). More than 87% of immigrants were on antiretroviral therapy (ART), although 26.6% of them were viremic. A 22.0% of immigrants had hepatitis (HBV and/or HCV) and/or tuberculosis. HIV phylogenetic analysis on sequences from 192 immigrants showed the presence of clades B (23.4%), G (16.1%), C (10.4%), A1 (9.4%), F1 (5.2%), D (1.6%) and Circulating Recombinant Forms (CRFs) (33.9%). CRF02_AG represented 72.3% of the total CRFs. Clusters between immigrants and Italian natives were also present. Drug resistance mutations to NRTI, NNRTI, and PI drug classes occurred in 29.1% of ART-treated and in 12.9% of ART-naïve individuals. These data highlight the need for tailored public health interventions in immigrants to avoid spreading in Italy of HIV genetic forms and ART-resistant variants, as well as HIV co-morbidities.

Published
2020

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