1. Zona pellucida shear modulus, a possible novel non-invasive method to assist in embryo selection during in-vitro fertilization treatment
- Author
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Yuval Perets, Tsvia Priel, Atif Zeadna, Eliahu Levitas, Irit Szaingurten-Solodkin, elad priel, Tamar Wainstock, Iris Har-Vardi, Avi Harlev, and Eitan Lunenfeld
- Subjects
0301 basic medicine ,Adult ,Pregnancy Rate ,Mathematics and computing ,medicine.medical_treatment ,lcsh:Medicine ,Logistic regression ,Intracytoplasmic sperm injection ,Article ,Andrology ,03 medical and health sciences ,0302 clinical medicine ,Human fertilization ,Medical research ,Pregnancy ,medicine ,Computational models ,Humans ,Single-Blind Method ,Embryo Implantation ,Sperm Injections, Intracytoplasmic ,Zona pellucida ,lcsh:Science ,Zona Pellucida ,Multidisciplinary ,In vitro fertilisation ,Chemistry ,lcsh:R ,Embryo ,Oocyte ,Confidence interval ,030104 developmental biology ,medicine.anatomical_structure ,Case-Control Studies ,Oocytes ,lcsh:Q ,Female ,Shear Strength ,030217 neurology & neurosurgery ,Maternal Age - Abstract
The present study investigated the association between oocyte zona pellucida shear modulus (ZPSM) and implantation rate (IR). Ninety-three oocytes collected from 38 in-vitro fertilization patients who underwent intracytoplasmic sperm injection were included in this case–control study. The ZP was modeled as an isotropic compressible hyperelastic material with parameter $$C_{10}$$ C 10 , which represents the ZPSM. Computational methodology was used to calculate the mechanical parameters that govern ZP deformation. Fifty-one developed embryos were transferred and divided into two groups—implanted and not implanted. Multivariate logistic regression analysis was performed to identify the association between ZPSM and IR while controlling for confounders. Maternal age and number of embryos per transfer were significantly associated with implantation. The IR of embryos characterized by $$C_{10}$$ C 10 values in the range of 0.20–0.40 kPa was 66.75%, while outside this range it was 6.70%. This range was significantly associated with implantation (p p = 0.001). The present study suggests that ZPSM may improve the classic embryo selection process with the aim of increasing IR.
- Published
- 2020