1. Walking on common ground: a cross-disciplinary scoping review on the clinical utility of digital mobility outcomes
- Author
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Thierry Troosters, Anja Frei, Clint Hansen, Gavin Brittain, Ashley Polhemus, Milo A. Puhan, Heleen Demeyer, Claudia Mazzà, Felix Kluge, Magda Bosch de Basea, Corinna Nerz, Francesca Salis, Gabriela Cardenas, Andrea Cereatti, Julia Gugenhan, Cameron Kirk, Kristin Taraldsen, Ronny Bergquist, Clemens Becker, Sabine Stallforth, Kirsty Scott, Parris J Williams, Judith Garcia-Aymerich, Nicholas S Hopkinson, Mobilise-D, Sarah Koch, Rachele Rossanigo, Christoph Endress, Heiko Gaßner, Alison Keogh, M. Encarna Micó-Amigo, Ellen Buckley, Basil Sharrack, Sara Buttery, Diletta Balta, Janet M.T. van Uem, Letizia Leocani, Laura Delgado Ortiz, Chloé Sieber, Lynn Rochester, A. Stefanie Mikolaizak, Nikolaos Chynkiamis, Michaela Gross, Sofie Breuls, Lars Schwickert, Walter Maetzler, Beatrix Vereijken, Alison J. Yarnall, and Ioannis Vogiatzis
- Subjects
Predictive validity ,medicine.medical_specialty ,Ecological validity ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Psychological intervention ,MEDLINE ,B100 ,Medicine (miscellaneous) ,Health Informatics ,Disease ,Review Article ,Predictive markers ,OBSTRUCTIVE PULMONARY-DISEASE ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,PARKINSONS-DISEASE ,Health Information Management ,QUALITY-OF-LIFE ,PEOPLE ,Medicine and Health Sciences ,Medicine ,030212 general & internal medicine ,OLDER-ADULTS ,Movement disorders ,Respiratory tract diseases ,Science & Technology ,Cross disciplinary ,business.industry ,USUAL GAIT SPEED ,Common ground ,MULTIPLE-SCLEROSIS ,A300 ,PERFORMANCE ,C600 ,3. Good health ,Computer Science Applications ,Mobilise-D ,Health Care Sciences & Services ,PHYSICAL-ACTIVITY ,Geriatrics ,PATIENT-REPORTED OUTCOMES ,Cadence ,business ,Life Sciences & Biomedicine ,Medical Informatics ,030217 neurology & neurosurgery - Abstract
Physical mobility is essential to health, and patients often rate it as a high-priority clinical outcome. Digital mobility outcomes (DMOs), such as real-world gait speed or step count, show promise as clinical measures in many medical conditions. However, current research is nascent and fragmented by discipline. This scoping review maps existing evidence on the clinical utility of DMOs, identifying commonalities across traditional disciplinary divides. In November 2019, 11 databases were searched for records investigating the validity and responsiveness of 34 DMOs in four diverse medical conditions (Parkinson's disease, multiple sclerosis, chronic obstructive pulmonary disease, hip fracture). Searches yielded 19,672 unique records. After screening, 855 records representing 775 studies were included and charted in systematic maps. Studies frequently investigated gait speed (70.4% of studies), step length (30.7%), cadence (21.4%), and daily step count (20.7%). They studied differences between healthy and pathological gait (36.4%), associations between DMOs and clinical measures (48.8%) or outcomes (4.3%), and responsiveness to interventions (26.8%). Gait speed, step length, cadence, step time and step count exhibited consistent evidence of validity and responsiveness in multiple conditions, although the evidence was inconsistent or lacking for other DMOs. If DMOs are to be adopted as mainstream tools, further work is needed to establish their predictive validity, responsiveness, and ecological validity. Cross-disciplinary efforts to align methodology and validate DMOs may facilitate their adoption into clinical practice. The Mobilise-D project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement no. 820820. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation program and the European Federation of Pharmaceutical Industries and Associations (EFPIA). This publication reflects the authors’ views and neither IMI nor the European Union, EFPIA, or any Associated Partners are responsible for any use that may be made of the information contained herein. H.D. is a postdoctoral research fellow of the FWO-Flanders. ISGlobal acknowledges support from the Spanish Ministry of Science, Innovation, and Universities through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program.
- Published
- 2021