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Currently there are a large number of publications, in which the data demonstrate advantages of laparoscopy-assisted colectomy against open surgery. These advantages include: fewer complications in the postoperative wounds, reducing the intensity of pain in the postoperative period, a decrease in length of hospital stay, faster recovery of bowel function in the postoperative period as well as the best cosmetic effect. Also it is proved that when performing laparoscopic surgery it is possible to achieve the criteria of oncological radicalism. A number of clinical studies have reported similar rates of a 3-and 5-year survival rate between these two approaches, which makes laparoscopy-assisted colectomy an attractive alternative to traditional open surgery. Despite significant advances in laparoscopic treatment for colon cancer surgeons are still faced limitations inherent to traditional laparoscopic technique. Development and distribution of surgical instruments for a robotic complex in the middle of the 2000s made it possible to overcome limitations through the use of tools with multiple degrees of freedom and stable three-dimensional high-definition images. The use of robotic technologies in laparoscopic surgery has showed their safety and effective alternative to standard laparoscopic surgery.

The paper summarizes and analyzes the results of complex treatment of patients with malignant tumors performed in the N.N.Petrov Research Institute of Oncology using perfusion technologies. Safety and efficacy data on various chemoperfusion is presented: intraperitoneal chemoperfusion combined with cytoreductive surgery in patients with locally advanced and disseminated gastric cancer, recurrent ovarian cancer and pseudomyxoma peritonei; isolated lung perfusion combined with metastasectomy in patients with lung metastases; isolated limb perfusion with/without cytoreduction in patients with locally advanced skin melanoma and locally advanced soft-tissue sarcoma. The conclusion is made that both intraperitoneal and isolated chemoperfusions are not associated with higher incidence of intra- and postoperative morbidity. However safety of the procedures could be increased through optimizing tactics of surgical procedures prior to chemoperfusions. The use of perfusion technologies provides significant survival advantage in patients who can’t benefit from conservative treatment.

Development of cancer surgery in recent decades occurs on a background of continuing scientific and technical progress. New technologies after the completion of clinical trials maximally quickly are included in the routine practice of specialized medical centers. At present an escalation of indications for extensive advanced and combined operations in locally advanced and even metastatic tumors goes in parallel with the introduction of minimally invasive interventions, search categories of patients, for whom the radicalism of treatment can be achieved without significant surgical aggression. The study of modern trends of this process will allow seeing the promising areas of scientific research, assuming the image of the future of surgery for cancer.

The main treatment option for rectal cancer is surgery, which "gold standard" is the total mesorectumectomy. There are presented literature review and the results of own research devoted to comparative analysis of outcomes of laparoscopic and open total mesorectumectomy. Current data and own experience show the oncological adequacy and safety of laparoscopic approach however the controversy of some results reveal the necessity of further investigation.

The data of literature on possibility of the use of perfusion technologies in combined treatment for malignant tumors of different sites are presented. Possible complications during hyperthermic chemoperfusion are discussed and the effectiveness of this method is analyzed.

During the period from April 2012 to December 2014 54 patients aged 29-76 years, 36 (66.6%) males and 18 (33.4%) females, with esophageal cancer underwent minimally invasive esophagectomy as final phase of treatment. Squamous cell carcinoma was diagnosed in 50 patients and adenocarcinoma identified in 4 patients. The disease was staged as follows: IA--5 (9.3%) patients, IB--11 (20.4%) patients, IIA-- (16,.%) cases, III -- (3,.%) cases, IIII --8 (33,.%), IIII -- (14,8%), III -- (1,.%). 37 (68,.%) patients had surgery after induction chemoradiation therapy. Of 54 surgical interventions there were 20 hybrid and 34 minimally invasive operations. 19 (35,.%) patients developed complications, postoperative mortality was 2 (3,.)%. Minimally invasive esophagectomy meets basic oncological principles and leads to tolerable short-term results.

In recent decades there has been achieved significant progress in treatment for colorectal cancer. Minimally invasive surgery (including robot-assisted) is rapidly gaining widespread acceptance in treatment of this form of cancer. Today robotic surgery is a revolutionary technology that opens a new stage in the development of surgery of the 21st century. Currently in the world there have been performed more than 2 million surgical interventions of the colon using a robotic surgical complex Da Vinci. To date it was accumulated a large number of single-center studies comparing laparoscopic and robot-assisted interventions in cancer of various parts of the colon for short-term and long-term treatment outcomes, which showed their effectiveness and safety. Modern colorectal surgery could not be imagined without the latest technology, the use of which directly affects the quality of life of patients after surgery.

Extralevatory surgery requires a use of additional techniques for closure of extensive defects of the pelvic floor. This study analyzed the results of 55 extralevatory abdomino-perineal extirpations of the rectum using a variety of methods of plastic of defects of the pelvic floor. There were performed 20 simple plastics, 13 alloplastics and 22 myoplastics. Complications in the perineal wound were observed in 10 (50%) cases after a simple plastic, 4 (32%) after plastic using mesh endoprosthesis and 5 (23%) after myoplastic. It is showed that the highest rate of postoperative complications in the perineal wound (up to 50%) occurs in a case of "simple" plastic. Complication rate reduces to 23-32% when alloplastic and myoplastic are used. It is concluded that alloplastic and myoplastic have significant advantages over the simple plastic.

The short-term treatment results of 91 patients with locally advanced rectal cancer are presented. All patients received surgical treatment and neoadjuvant chemotherapy. The chemoradiotherapy effect was evaluated by comparison of pre- and post-therapeutic MRI data. MRI data was also compared with post-operation tumor morphology data. In 23% of resected tumor samples complete tumor regression was evident, in 47.2% of cases partial regression was revealed. Lymph node metastases were found in 21.9% of cases. The discrepancy in MRI and morphology data can be explained by the limited ability of MRI in differentiation between viable tumor, fibronecrotic tissue and inflammatory reaction after chemoradiotherapy.

Locally-advanced gastric cancer features predominance of prognostically unfavorable histological patterns (infiltrative growth--in 87.9%, tumor grades II-IV--69.5%). Tumor invasion into two adjacent organs or more frequently occurs in totally-involved stomach (65.2+/-9.7%), poorly-differentiated (grade Ill) tumors (44.9+/-4.5%) under-differentiated ones (grade IV) (45.9+/-8.2%). Invasion into one adjacent organ is significantly predominant (p

Results of surgical treatment of 223 patients with locally advanced gastric cancer (2000-2005) are presented. Postoperative complications rate was 25.6 +/- 2.5%, mortality--5.8 +/- 0.7%, overall survival--17.9 +/- 2.6%, median survival--12 months. Survival rates were higher following palliative treatment. Groups of patients in which RO resections failed to improve the end results were identified. That in turn calls for working out differentiated surgical strategies.