1. [Cell differentiation in human melanoma cells caused by dicarbamine (ultrastructural investigation)].
- Author
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Raĭkhlin NT, Nebol'sin VE, Zheltukhina GA, Bryzgalov IP, Sorokina IuD, Andronova NV, Sedakova LA, Smirnova EA, and Treshchalina EM
- Subjects
- Animals, Cell Differentiation drug effects, Humans, Immunohistochemistry, Melanosomes chemistry, Mice, Mice, Nude, Microscopy, Electron, Neoplasm Transplantation, Antineoplastic Agents pharmacology, Carbamates pharmacology, Melanins analysis, Melanoma, Experimental drug therapy, Melanoma, Experimental ultrastructure, Melanosomes drug effects, Tretinoin pharmacology
- Abstract
The effects of dicarbamine (r) and polytransretinoic acid (PTRA) on human melanoma MEL-6 transplanted into Balb/c nude female mice have been compared by histological and electron microscopic procedures. It was discovered that long-term administration of 1.5 mg/kg dicarbamine caused melanoma MEL-6 cells to undergo terminal differentiation. As a result, the number of melanosome-containing cells was 3-4 times and the number of melanosomes in them--5 times those in intact controls. Dicarbamine effect was double that of PTRA.
- Published
- 2003