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The article focuses on the study regarding the impact of preexposure prophylaxis for HIV. It states that there was a possibility of developing resistance tot the antiviral agents used in the HIV acquired during preexposure prophylaxis. It says that a management plan was needed when recommending preexposure prophylaxis which recognizes the intervention's effect on the sexual behavior and well-being of the patient.

The author discusses concerns about the optimal time to start antiretroviral therapy in asymptomatic patients. The topic has become a central controversy in the care of HIV patients since the introduction of antiretroviral agent zidovudine. Particular attention is paid to the results of a study published in this issue of the journal titled "Effect of early versus deferred antiretroviral therapy for HIV on survival."